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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Difference in transducin-like enhancer of split 1 protein expression between basal cell adenomas and basal cell adenocarcinomas - an immunohistochemical study

Fig. 3

Basal cell adenocarcinoma (BCAC). BCAC histology (a: low magnification, a1: high magnification of square 1, a2: high magnification of square 2) with hematoxylin-eosin staining are shown. A multinodular tumor (a) forms a tubular, trabecular, solid growth pattern in non-invasive areas (a1), and small tumor nests infiltrate the surrounding parenchyma (a2). They show slightly increased mitotic activity (arrows in a2). BCAC of non-invasive areas (b-d) and invasive areas (e-g) with TLE1(b, e), β-catenin (c, f), and α-SMA (d, g) immunostaining, respectively, are shown. In non-invasive areas, luminal cells are positive for TLE1(b), abluminal cells are positive for β-catenin(c), and the lining of myoepithelial cells are positive for α-SMA(d). In invasive areas, luminal cells staining for TLE1(e) becomes indistinct, abluminal cells positivity for β-catenin(f) remains unchanged, and the α-SMA(g) lining myoepithelial cells disappear. Mutational analysis for CTNNB1 detected the same mutation on both areas of the tumor (h: non-invasive areas, i: invasive areas, BCAC case 1)

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