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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Melanotic Xp11 translocation renal cancer: a report of a distinctive case and a review of the literature

Fig. 3

a The elastic fibers of thick-walled blood vessels are highlighted by Gomrori’s aldehyde-fuchsin staining (× 100). The cytoplasmic pigment is positive for Fontana-Masson staining (b) (× 100); it was removed by potassium permanganate bleaching (c) (× 100). Tumor cells exhibit diffuse nuclear immunoreactivity for TFE3 (d) (IHC staining, × 100) and patchy cytoplasmic positivity for HMB45 (e) (IHC staining, × 100). f Break-apart FISH for TFE3 produced normal fused signals and split signals (arrows); one pair of each type of signal is depicted (× 1000)

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