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Table 2 The somatic mutation spectrum in different renal carcinoma

From: Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases

  Present study
(n = 28)
Renal Clear Cell Carcinoma
(n = 499)
Wilms Tumor
(n = 102)
Papillary Renal Cell Carcinoma (n = 293)
Gene Mutant Freq Gene Mutant Freq Gene Mutant Freq Gene Mutant Freq
1 BRAF 23 82% VHL 235 51% TP53 15 15% MET 23 7%
2 NF1 6 21% PBRM1 158 36% HLA-DQB1 11 7% KMT2C 20 6%
3 NOTCH1 5 18% MUC4 142 21% CTNNB1 8 7% MUC4 20 5%
4 SPEN 5 18% SETD2 60 13% CDK11A 6 6% SETD2 19 6%
5 AKT2 4 14% BAP1 44 10% DROSHA 7 6% KIAA1109 17 6%
6 APC 4 14% KDM5C 30 7% TMPRSS13 5 4% BAP1 16 5%
7 ATRX 3 11% MTOR 23 5% ADCK5 4 4% AR 16 5%
8 ETV4 3 11% PABPC1 20 5% WT1 4 4% KMT2D 15 5%
9 FANCD2 2 7% AHNAK2 19 4% SIX1 4 4% PCLO 14 4%
10 FAT3 2 7% PTEN 19 4% MAP3K4 4 4% FAT1 13 4%
11 KDM6A 2 7% ATM 18 3% ACTB 3 3% NEFH 13 4%
12 KDR 2 7% KMT2C 17 4% ZNF880 3 3% WDFY3 13 4%
13 NOTCH3 2 7% MAGEC1 16 4% ZNF595 3 3% SYNE1 13 4%
14 TET2 2 7% MUC6 16 3% DGCR8 3 3% CUL3 13 4%
15 TSC2 2 7% LRP1B 15 4% AGRN 3 3% ZNF814 13 3%
16     PCLO 15 4% MADCAM1 4 3% ALMS1 13 3%
17     SYNE1 15 4% HYDIN 3 3% DNAH8 12 4%
18     ARID1A 14 3%     CUBN 12 4%
19     KMT2D 14 3%     PBRM1 12 4%
20     MUC2 14 3%     PCF11 12 4%