Fig. 2

Inmunohistochemistry. a Osteoclast-like giant cells were positive for CD68. In contrast, neoplastic cells were negative for CD68 (arrows). b Neoplastic cells were positive for cytokeratin (CK) AE1/AE. In contrast, Osteoclast-like giant cells were negative for CK AE1/AE3 (arrows). Both (c) the invasive component and (d) the in situ component showed complete absence of expression for E-cadherin