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Fig. 5 | Diagnostic Pathology

Fig. 5

From: Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma

Fig. 5

RNAi was utilized to silence Tyk2 expression in CLDN17-expressing cells. a Western blotting was utilized to examine the effects of silencing Tyk2 and activating the Stat3 signaling pathway in the HL7702 cell line; (b) The corresponding statistical analysis of the activation of the Stat3 signaling pathway; (c) The Transwell chamber method was utilized to detect the impact of Tyk2 silencing on the invasive ability of the cells in vitro; (d) The corresponding statistical analysis of invaded cells; (e) A wound healing assay was utilized to detect the migration ability of the HL7702 cell line in vitro. Note: * represents P < 0.05 and ** represents P < 0.01 compared with the scramble group

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