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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor

Fig. 3

Pathological findings of CCSLGT with EWSR1 and CREB1 rearrangements. a CCSLGTs often exhibited sheet-like proliferation of polyhedral and epithelioid tumor cells (200×). b Areas of pseudo-papillary growth pattern around the vasculatures were also observed (200×). c Tumor cells had mildly irregular-shaped round nuclei showing a coarse chromatin pattern and lightly eosinophilic to less frequently clear cytoplasm. Nucleoli were inconspicuous (400×). d Osteoclast-type giant cells were scattered in the tumor (400×). e. FISH of EWSR1 split signals. Tumor cells showed EWSR1 split signal with a pair of fused (arrow) and split (arrow head) patterns (1000×). f. FISH of CREB1 split signals. Tumor cells showed CREB1 split signal with a pair of fused (arrow) and split (arrow head) patterns (1000×)

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Diagnostic Pathology

ISSN: 1746-1596

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