Skip to main content

Table 1 Summary of clinical, immunohistochemical, and genetic findings of CCSST and CCSLGT cases

From: Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor

No.

Age (years) /Sex

Location

Tumor size (cm)

Outcome (months)

Immunohistochemistry

Fluorescence in situ hybridization (%)

Expected fusion genes by FISH

RT-PCR findings

S-100 protein

Melan-A and/or HMB45

SOX-10

EWSR1

ATF1

CREB1

CREM

1

29/F

Leg

5

DOD (73)

+

+

NP

72

48

2

NP

EWSR1-ATF1

NP

2

41/M

Leg

4

DOD (62)

+

+

NP

68

ND

ND

NP

EWSR1- (unknown partner)

NP

3

25/M

Leg

8

DOD (29)

+

+

NP

50

32

4

NP

EWSR1-ATF1

EWSR1 exon 8-ATF1 exon 4

4

62/F

Leg

2

NED (6)

+

+

NP

8

6

0

NP

Unknown

EWSR1 exon 8-ATF1 exon 4

5

33/M

Leg

2.5

DOD (8)

+

+

NP

16

0

0

NP

EWSR1- (unknown partner)

EWSR1 exon 10-ATF1 exon 5

6

34/F

Leg

NA

AWD (16)

+

+

NP

62

32

0

NP

EWSR1-ATF1

NP

7

34/M

Leg

6

AWD (9)

+

+

NP

76

66

6

NP

EWSR1-ATF1

NP

8

12/F

Leg

2

NED (96)

+

–

–

36

0

2

2

EWSR1-(unknown partner)

NP

9

39/F

Arm

3

DOD (10)

+

+

NP

74

54

ND

NP

EWSR1-ATF1

NP

10

69/F

Arm

2

DOD (26)

+

+

NP

50

58

0

NP

EWSR1-ATF1

EWSR1 exon 8-ATF1 exon 4

11

41/M

Arm

2.5

AWD (11)

+

+

NP

58

58

2

NP

EWSR1-ATF1

EWSR1 exon 10-ATF1 exon 5

12

40/M

Arm

5.5

AWD (23)

+

+

NP

70

36

8

NP

EWSR1-ATF1

EWSR1 exon 8-ATF1 exon 5

13

49/F

Arm

4

AWD (24)

+

+

NP

70

8

4

36

EWSR1-CREM

*

14

56/F

Arm

3.9

AWD (3)

+

+

NP

80

86

2

0

EWSR1-ATF1

NP

15

8/F

Abdominal wall

9.5

DOD (249)

+

+

NP

50

36

0

NP

EWSR1-ATF1

NP

16

43/M

Skin

3

NED (29)

+

–

NP

84

76

0

NP

EWSR1-ATF1

NP

17

41/F

Ileum

4

NED (28)

+

–

NP

72

58

2

NP

EWSR1-ATF1

NP

18

78/F

Ileum

9

NED (48)

+

–

+

2

2

0

12

(unknown partner)-CREM

NP

19

38/F

Small intestine

10

DOD (17)

+

–

NP

56

6

42

NP

EWSR1-CREB1

NP

20

20/F

Ileum

4

NED (7)

+

–

+

80

94

4

NP

EWSR1-ATF1

EWSR1 exon 8-ATF1 exon 4

21

47/F

Ileum

4.5

AWD (34)

+

–

+

74

0

62

NP

EWSR1-CREB1

EWSR1 exon 7-CREB1 exon 7

22

57/M

Esophagus

3

NED (18)

+

–

+

2

2

0

8

Unknown

NP

  1. + Positive, − Negative, AWD Alive with disease, NED No evidence of disease, DOD Died of disease, NA Not available, ND Not detected, NP Not performed, FISH Fluorescence in situ hybridization, RT-PCR Reverse transcription PCR; *, fusion gene was not detected by RT-PCR in formalin-fixed, paraffin-embedded materials