Release of circulating tumor cells and cell-free nucleic acids is an infrequent event in synovial sarcoma: liquid biopsy analysis of 15 patients diagnosed with synovial sarcoma

Table 1 Clinical characteristics of the synovial sarcoma cohort

Case	Site^a	Size^b (cm)	Therapy	Site of metastasis	Size of recurrence^c (cm)	Subtype
1	right leg	5.5	SX + ChT	mpx lung, bone, CNS	no recurrence	monophasic
2	left ankle	4	SX + ChT	lung	no recurrence	biphasic
3	lung	NA	SX + ChT	lung	no recurrence	biphasic
4	gluteal region	7	SX + ChT	no metastasis	no recurrence	monophasic
5	left hand	1	SX + ChT	mpx lung	2.8	monophasic
6	left praesacral region	NA	SX + ChT	mpx lung	4	monophasic
7	left leg	NA	SX + ChT	mpx lung, liver	3	monophasic
8	abdominal wall	10	SX + ChT	no metastasis	3.5	monophasic
9	right palm	3	SX	no metastasis	1.5	biphasic
10	neck	NA	SX + RT + ChT	no metastasis	no recurrence	monophasic
11	left forearm	NA	SX + ChT	lung	2.1	monophasic
12	right forearm	3.9	SX + ChT	mpx lung, mediastinum	no recurrence	monophasic
13	right popliteal region	10	SX + ChT	mpx lung, kidney	NA	monophasic
14	right sole	5	SX + ChT	no metastasis	no recurrence	monophasic
15	left leg	NA	SX + ChT	mpx lung, pleura, mediastinum	no recurrence	biphasic

^alocation of the primary tumor; ^bmaximum diameter of the primary tumor; ^cmaximum diameter of the recurrent tumor; NA not available, SX surgical excision, ChT chemotherapy, RT radiotherapy, mpx multiplex, CNS central nervous system. Chemotherapy means the combination of the following agents: Epirubicin; VIP: 3 cycles of Etoposide, Ifosfamide and Cisplatin; Bisphosphonate; Dacarbazine; Vincristine; Pazopanib; Doxorubicin; Ifosfamide; Gemcytabine; Docetaxel; Carboplatin; Etoposide; CYVADIC: Cyclophosphamide, Vincristine, Adriamycin, Dacarbazine

ISSN: 1746-1596