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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Robustness of biomarker determination in breast cancer by RT-qPCR: impact of tumor cell content, DCIS and non-neoplastic breast tissue

Fig. 4

Effect of DCIS on relative gene expression. a Representative images (sample 17) of H&E stained, HER2 immunostained and cresyl violet stained sections before and after microdissection of DCIS-only areas. b-e Shown in the graph are gene expression data for n = 24 breast cancer specimen for ERBB2 (b), ESR1 (c), PGR (d) and MKI67 (e) of paired whole tissue sections (green circles), whole tissue sections without DCIS (blue squares) and DCIS-enriched (orange triangles) microdissected tissue. Dotted lines represent the respective cut-off for the four marker genes. (ERBB2: 41.10; ESR1: 38.00; PGR: 35.50; MKI67: 35.90)

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Diagnostic Pathology

ISSN: 1746-1596

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