Table 1 Reported cases of ENKTCL with low-grade histological findings
Case | Citation | Gender | Age | Site | Presentation | Angioinvasion/ necrosis | Atypia | Ki-67 | Immunophenotype | Description/Follow-up |
|---|---|---|---|---|---|---|---|---|---|---|
1 | Seishima et al. [16] | F | 60 | Skin | Recurrent swelling upper lip initially diagnosed as “lymphoid proliferation associated with EBV” | No | No | NR | CD45RO+, EBER+, CD56-, CD20- | Developed ENKTCL-NT with angioinvasion and necrosis involving facial skin and nasal tract 9.5 years later, died despite treatment |
2 | Zhang et al. [17] | F | 53 | Sinonasal | History of chronic rhinosinusitis with nasal polyps removed 20 years prior; Progressive nasal obstruction | No | Mild | 80% | cCD3+, CD56+, Granzyme-B+, EBER+, TIA-1+, CD20- | Treated with chemotherapy and radiation, disease-free at 4 month follow-up |
3 | Tabanelli et al. [18] | M | 52 | Sinonasal | History of chronic rhinosinusitis for 13 years with eventual sinonasal thickening obliterating right maxillary sinus and nasal turbinate | No | Mild | Moderately high | CD2+, CD3+, CD56+, Granzyme-B+, EBER+, CD4-, CD5-, CD7-, CD8- | Initially diagnosed as EBV-associated proliferation, persisted for 2 years and diagnosed as ENKTCL-NT on a rebiopsy; long term follow-up not available |
4–6 | Hasserjian et al. [19] | NR | NR | Sinonasal | unknown | No | No | NR | NR | Remained indolent for 10 years, recurred secondary to immunosuppression for renal transplant |
NR | NR | Sinonasal | unknown | No | No | NR | NR | Bland histologic appearance resembling inflammatory infiltrate, no further description | ||
NR | NR | Sinonasal | unknown | No | No | NR | NR | |||
7 | Zuriel et al. [20] | F | 55 | Skin | Large red violaceous infiltrated plaques | No | No | > 90% | CD2+,cCD3+, CD56-, Granzyme B+, EBER+, CD4-, CD5-,CD8- | Indolent course over 22 years with only local skin recurrences treated by local radiotherapy |
8 | Current Case | F | 71 | Sinonasal | History of longstanding chronic rhinosinusitis, sinonasal thickening/polyp | No | Mild | < 1% | CD2+, cCD3+, CD5(dim)+, Perforin+, Granzyme-B+, EBER+, CD56-, CD30- | Treated with radiation, no recurrence at 6 month follow-up |