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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study

Fig. 2

Immunohistochemical staining in a representative case of sessile serrated adenoma/polyp (SSA/P) with dysplasia (Case #2). a Dilated crypts and deep serration, corresponding to SSA/P, were seen on the left side, and high-grade dysplasia without submucosal invasion was seen on the right side. An abrupt transition was seen between the 2 adjacent regions (arrow). b High-power field of (a) (the right side). A view shows high-grade dysplasia without submucosal invasion, which was pathologically consistent with SSA/P with cytologic dysplasia. The lesion showed nuclear β-catenin expression (c) and a loss of MLH1 expression (d). Regarding phenotypic mucin expression, the lesion was positive for MUC2 (e), MUC5AC (f), and MUC6 (g) expression, and negative for CD10 (H) expression

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Diagnostic Pathology

ISSN: 1746-1596

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