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Table 2 Summary of molecular biological features in each case of sessile serrated adenoma/polyp (SSA/P) with dysplasia and invasive adenocarcinoma

From: Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study

Case No.

Group

Immunohistochemistry

Next generation sequencing analysis (Gene mutations)

MSI analysis

MLH1 loss

β-catenin

MUC2

MUC5AC

MUC6

CD10

BRAF

FBXW7

KIT

PTEN

SMAD4

SMARCB1

TP53

1

Dysplasia

–

+

+

+

+

–

+

–

–

–

–

–

+

MSS

2

Dysplasia

+

+

+

+

+

–

+

–

–

–

–

–

–

MSI-high

3

Dysplasia

+

+

+

+

+

–

+

+

+

–

+

–

–

MSI-high

4

Dysplasia

–

+

+

+

+

–

+

–

–

+

–

+

–

MSS

5

Carcinoma

+

+

+

+

+

–

+

–

–

–

–

–

–

MSS

6

Carcinoma

–

+

+

–

–

–

+

–

–

–

–

–

+

MSS

7

Carcinoma

+

+

+

+

+

–

–

+

–

–

–

–

–

MSI-high

8

Carcinoma

+

+

+

+

+

–

+

+

–

–

–

–

–

MSI-high

  1. Dysplasia, SSA/P with high-grade dysplasia; Carcinoma, SSA/P with submucosal carcinoma; MSI-high, Microsatellite instability-high; MSS, Microsatellite-stable; +, present; −, absent