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Table 2 Summary of molecular biological features in each case of sessile serrated adenoma/polyp (SSA/P) with dysplasia and invasive adenocarcinoma

From: Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study

Case No. Group Immunohistochemistry Next generation sequencing analysis (Gene mutations) MSI analysis
MLH1 loss β-catenin MUC2 MUC5AC MUC6 CD10 BRAF FBXW7 KIT PTEN SMAD4 SMARCB1 TP53
1 Dysplasia + + + + + + MSS
2 Dysplasia + + + + + + MSI-high
3 Dysplasia + + + + + + + + + MSI-high
4 Dysplasia + + + + + + + MSS
5 Carcinoma + + + + + + MSS
6 Carcinoma + + + + MSS
7 Carcinoma + + + + + + MSI-high
8 Carcinoma + + + + + + + MSI-high
  1. Dysplasia, SSA/P with high-grade dysplasia; Carcinoma, SSA/P with submucosal carcinoma; MSI-high, Microsatellite instability-high; MSS, Microsatellite-stable; +, present; −, absent