Table 2 Relationships between clinicopathological characteristics and PD-L1 expression in tumor cells
Clinicopathological characteristics | Overall | PD-L1 (+) | PD-L1 (−) | Odds ratio (95% CI) | Global P |
|---|---|---|---|---|---|
378 | 113(29.9%) | 265(70.1%) | |||
Age at diagnosis | 1.563(1.003–2.438) | 0.049 | |||
≥ 60 years | 188 | 65(34.6%) | 123(65.4%) | ||
< 60 years | 190 | 48(25.3%) | 142(74.7%) | ||
Gender | 0.800(0.461–1.386) | 0.425 | |||
Male | 307 | 89(29.0%) | 218(71.0%) | ||
Female | 71 | 24(33.8%) | 47(66.2%) | ||
Tumor differentiation | |||||
Well | 85 | 21(24.7%) | 64(75.3%) | 1 | |
Moderate | 190 | 51(26.8%) | 139(73.2%) | 1.118(0.621–2.013) | 0.710 |
Poor | 91 | 38(41.8%) | 53(58.2%) | 2.185(1.146–4.166) | 0.018 |
Basaloid | 12 | 3(25.0%) | 9(75.0%) | 1.016(0.251–4.105) | 0.982 |
Location | |||||
Upper thoracic | 61 | 18(29.5%) | 43(70.5%) | 1 | |
Middle thoracic | 209 | 59(28.2%) | 150(71.8%) | 0.940(0.502–1.759) | 0.846 |
Lower thoracic | 108 | 36(33.3%) | 72(66.7%) | 1.194(0.605–2.358) | 0.609 |
PT status | 1.821(1.068–3.106) | 0.028 | |||
pT2 | 103 | 22(21.4%) | 81(78.6%) | ||
pT3-4a | 275 | 91(33.1%) | 184(66.9%) | ||
PN status | 1.541(1.210–1.963) | < 0.001 | |||
pN0 | 189 | 40(21.2%) | 149(78.8%) | ||
pN1 | 116 | 43(37.1%) | 73(62.9%) | ||
pN2 | 52 | 20(38.5%) | 32(61.5%) | ||
pN3 | 21 | 10(47.6%) | 11(52.4%) | ||
Vascular invasion | 1.025(0.656–1.600) | 0.915 | |||
No | 219 | 65(29.7%) | 154(70.3%) | ||
Yes | 159 | 48(30.2%) | 111(69.8%) | ||
Perineural invasion | 0.823(0.512–1.324) | 0.422 | |||
No | 253 | 79(31.2%) | 174(68.8%) | ||
Yes | 125 | 34(27.2%) | 91(72.8%) | ||
Metachronous hematogenous metastasis | 2.030(1.171–3.520) | 0.012 | |||
No | 313 | 85(27.2%) | 228(72.8%) | ||
Yes | 65 | 28(43.1%) | 37(56.9%) | ||