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Table 5 Univariate COX analysis to determine factors associated with patient survival for PD-L1 expression in tumor cells

From: PD-L1 expression and its clinicopathological correlation in advanced esophageal squamous cell carcinoma in a Chinese population

Variables

Overall survival

Disease-free survival

Hazard ratios

95%CI

P value

Hazard ratios

95%CI

P value

PD-L1

 Negative

1

  

1

  

 Positive

1.240

0.929-1.653

0.144

1.436

1.095-1.883

0.009

Age

 <60 years

1

  

1

  

 ≥60 years

1.303

0.995-1.705

0.054

1.205

0.932-1.557

0.154

Gender

Female

1

  

1

  

Male

1.033

0.737-1.448

0.849

0.942

0.684-1.297

0.714

Tumor differentiation

 Well

1

  

1

  

 Moderate

1.383

0.954-2.005

0.087

1.458

1.025-2.074

0.036

 Poor

2.150

1.435-3.222

<0.001

2.180

1.478-3.216

<0.001

 Basaloid

1.774

0.828-3.804

0.141

2.162

1.052-4.444

0.036

Location

 Upper thoracic

1

  

1

  

 Middle thoracic

0.872

0.602-1.262

0.468

0.960

0.669-1.379

0.826

 Lower thoracic

0.798

0.529-1.204

0.282

0.900

0.604-1.341

0.604

PT status

 pT2

1

  

1

  

 pT3-4a

1.348

0.984-1.847

0.063

1.377

1.019-1.859

0.037

PN status

 pN0

1

  

1

  

 pN1

2.175

1.575-3.002

<0.001

2.277

1.681-3.084

<0.001

 pN2

3.703

2.542-5.394

<0.001

3.291

2.284-4.744

<0.001

 pN3

9.401

5.707-15.486

<0.001

8.029

4.875-13.225

<0.001

Vascular invasion

 No

1

  

1

  

 Yes

1.853

1.415-2.427

<0.001

1.714

1.326-2.218

<0.001

Perineural invasion

 No

1

  

1

  

 Yes

1.707

1.297-2.245

<0.001

1.645

1.267-2.138

<0.001

Metachronous hematogenous metastasis

 No

1

  

1

  

 Yes

2.533

1.868-3.435

<0.001

3.638

2.716-4.873

<0.001