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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary

Fig. 1

Photomicrographs of pagetoid urothelial intraepithelial neoplasia extending to the vagina. a–h Liquid-based cytology by vaginal scraping. a Stratified or linear clusters of atypical cells with partially necrotic changes (Papanicolaou [Pap] stain, × 200). b Cluster exhibiting nuclear stratification and disarrangement with cytoplasmic vacuoles and enlarged nucleoli (Pap, × 400). c Cell cannibalism in the margin of the cluster (Pap, × 1000). d CINtec® PLUS test demonstrating positive red nuclear labeling with Ki-67, but weak brown staining for p16 considered negative (immunocytochemical [ICC] stain, × 400). e Positivity for CK7 (ICC, × 200). f Positivity for CK20 (ICC, × 200). g Positivity for p63 (ICC, × 200). h Positivity for GATA3 (ICC, × 200)

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Diagnostic Pathology

ISSN: 1746-1596

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