Table 8 Associations between clinicopathological features and ALK rearrangement
Variable | ALK neg. (n = 348) | ALK pos. (n = 28) | p-value |
|---|---|---|---|
Age (years) | 64.4 ± 11.2 | 61.7 ± 14.1 | 0.229 |
Gender | Â | Â | 0.920 |
 Male | 183 (52.6) | 15 (53.6) |  |
 Female | 165 (47.4) | 13 (46.4) |  |
Smoking status | |||
 Never smokers | 72 (20.7) | 12 (42.9) | 0.007 |
 Ex-smokers | 124 (35.6) | 9 (32.1) | 0.710 |
 Current smokers | 152 (43.7) | 7 (25.0) | 0.054 |
Clinical stage | |||
 I | 22 (6.3) | 2 (7.1) | 0.697 |
 II | 29 (8.3) | 2 (7.1) | 0.822 |
 III | 67 (19.3) | 10 (35.7) | 0.038 |
 IV | 230 (66.1) | 14 (50.0) | 0.086 |
T stage | |||
 T1 | 47 (13.5) | 6 (21.4) | 0.258 |
  T1a | 8 (2.3) | 0 (0.0) | 0.263 |
  T1b | 19 (5.5) | 5 (17.9) | 0.025 |
  T1c | 20 (5.7) | 1 (3.6) | 0.608 |
 T2 | 88 (25.3) | 7 (25.0) | 0.973 |
  T2a | 59 (17.0) | 4 (14.3) | 0.711 |
  T2b | 29 (8.3) | 3 (10.7) | 0.721 |
 T3 | 70 (20.1) | 4 (14.3) | 0.455 |
 T4 | 143 (41.1) | 11 (39.3) | 0.852 |
LN metastasis/−es | 259 (74.4) | 24 (85.7) | 0.183 |
N stage | |||
 N0 | 89 (25.6) | 4 (14.3) | 0.183 |
 N1 | 50 (14.4) | 1 (3.6) | 0.151 |
 N2 | 93 (26.7) | 15 (53.6) | 0.003 |
 N3 | 116 (33.3) | 8 (28.6) | 0.606 |
Extrathoracic metastasis/−es | 161 (46.3) | 7 (25.0) | 0.029 |
M stage | |||
 M0 | 116 (33.3) | 14 (50.0) | 0.074 |
 M1a | 71 (20.4) | 7 (25.0) | 0.564 |
 M1b | 56 (16.1) | 0 (0.0) | 0.013 |
 M1c | 105 (30.2) | 7 (25.0) | 0.565 |
Localization | |||
 Right upper lobe | 96 (27.6) | 0 (0.0) | 0.001 |
 Right lower lobe | 51 (14.7) | 5 (17.9) | 0.587 |
 Middle lobe | 11 (3.2) | 4 (14.3) | 0.019 |
 Left upper lobe | 66 (19.0) | 6 (21.4) | 0.750 |
 Left lower lobe | 43 (12.4) | 6 (21.4) | 0.236 |
 Lingula | 11 (3.2) | 1 (3.6) | 0.611 |
 Involvement of two lobes | 70 (20.1) | 6 (21.4) | 0.868 |
Distribution | |||
 Central | 70 (20.1) | 8 (28.6) | 0.288 |
 Peripheral | 244 (70.1) | 16 (57.1) | 0.153 |
 Central and peripheral | 34 (9.8) | 4 (14.3) | 0.508 |
Size (mm) | 44.5 ± 24.4 | 46.0 ± 31.7 | 0.761 |