Fig. 3
From: Histologic findings associated with laser interstitial thermotherapy for glioblastoma multiforme
Histologic analysis of laser-induced thermal therapy treated left temporal glioblastoma multiforme revealed distinct histologic zones. Hematoxylin and eosin stained sections represent neoplastic tissue surrounded by granulation tissue and necrosis. Section images were captured (original magnification 4X) and collaged. Higher-magnification of a necrotic area (Zone 1), b granulation tissue (Zone 2) and d tumor (Zone 3). c Macrophages detected by CD68 immunohistochemistry in granulation tissue. e Glial fibrillary acidic protein stained astrocytes (f, g and h). Single cells with positivity for f Ki67, g p53 and h Olig2 consistent with viable glioma