From: Melanoma arising in a Giant congenital melanocytic nevus: two case reports
Author, Case № | Sex | Age at diagnosis (years) | Outcome/time after diagnosis | MRI CNS | Primary melanoma site | Tissue for genetic analysis | Genetics |
---|---|---|---|---|---|---|---|
Literature data | |||||||
Streams et al., Case 1 [7] | Female | 44 | Alive | Not done | Primary malignant melanoma of the left forearm underneath an intact skin graft 40 years after having had a partial excision and grafting of her GCMN | Not done | Not done |
Tchernev et al., Case 1 [8] | Female | 61 | Alive | Not done | Malignant melanoma of the occipital region (stage IIB) | Not done | Not done |
Lalor et al., Case 1 [35] | Female | 8 | Alive | Normal | Nodular melanoma on the scalp | Primary tumor | NRAS Q61R mutation |
De la Rosa Carillo [9] | 0 d | Died, 5mo | NCM | Large, multilobular, pigmented lesion covering 35% of the body, atypical melanocytic proliferation. Congenital melanoma. | Several biopsies | NRAS Wild-type, BRAF Wild-type | |
Kinsler et al., Case 4 [22] | Male | 15, 5 | Alive, 11 mo | Normal | Cutaneous, within largest CMN on the back of the scalp and neck, metastatic to local lymph node at time of diagnosis | Cutaneous melanoma | NRAS Wild-type |
Kinsler et al., Case 10 [22] | Male | Not known | Death, age 2,4 years | Normal | Lymph node groin, locally recurrent despite excision, local metastasis | Not done | Not done |
Kinsler et al., Case 12 [22] | Female | 6,5 | Death, 6 mo | Normal | Cutaneous, within largest CMN, at the site of postnatal resection of a benign congenital nodule, metastatic to local lymph node at time of diagnosis | Cutaneous melanoma | NRAS Q61K mutation |
Maguire et al., Case 2 [31] | Female | 7 mo | Alive, 9 mo | Not done | Cutaneous, on the groin site. A wide local excision was done. At 16 months of age enlarged node in the groin, metastatic melanoma | Not done | Not done |
Own experience | |||||||
Case 1 | Male | 22 d | Alive | NCM | Congenital cutaneous malignant melanoma of the lumbar-sacral part | Primary tumor | NRAS Wild-type, BRAF Wild-type |
Case 2 | Male | 5 mo | Alive | Normal | Congenital cutaneous malignant melanoma of the back of the neck | Primary tumor | NRAS Q61R mutation |