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Table 1 Clinical and genetic features of patients with congenital melanocytic naevus (CMN) and melanoma: literature data and own experience

From: Melanoma arising in a Giant congenital melanocytic nevus: two case reports

Author, Case № Sex Age at diagnosis (years) Outcome/time after diagnosis MRI CNS Primary melanoma site Tissue for genetic analysis Genetics
Literature data
Streams et al., Case 1 [7] Female 44 Alive Not done Primary malignant melanoma of the left forearm underneath an intact skin graft 40 years after having had a partial excision and grafting of her GCMN Not done Not done
Tchernev et al., Case 1 [8] Female 61 Alive Not done Malignant melanoma of the occipital region (stage IIB) Not done Not done
Lalor et al., Case 1 [35] Female 8 Alive Normal Nodular melanoma on the scalp Primary tumor NRAS Q61R mutation
De la Rosa Carillo [9]   0 d Died, 5mo NCM Large, multilobular, pigmented lesion covering 35% of the body, atypical melanocytic proliferation. Congenital melanoma. Several biopsies NRAS Wild-type, BRAF Wild-type
Kinsler et al., Case 4 [22] Male 15, 5 Alive, 11 mo Normal Cutaneous, within largest CMN on the back of the scalp and neck, metastatic to local lymph node at time of diagnosis Cutaneous melanoma NRAS Wild-type
Kinsler et al., Case 10 [22] Male Not known Death, age 2,4 years Normal Lymph node groin, locally recurrent despite excision, local metastasis Not done Not done
Kinsler et al., Case 12 [22] Female 6,5 Death, 6 mo Normal Cutaneous, within largest CMN, at the site of postnatal resection of a benign congenital nodule, metastatic to local lymph node at time of diagnosis Cutaneous melanoma NRAS Q61K mutation
Maguire et al., Case 2 [31] Female 7 mo Alive, 9 mo Not done Cutaneous, on the groin site. A wide local excision was done. At 16 months of age enlarged node in the groin, metastatic melanoma Not done Not done
Own experience
 Case 1 Male 22 d Alive NCM Congenital cutaneous malignant melanoma of the lumbar-sacral part Primary tumor NRAS Wild-type, BRAF Wild-type
 Case 2 Male 5 mo Alive Normal Congenital cutaneous malignant melanoma of the back of the neck Primary tumor NRAS Q61R mutation