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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities

Fig. 1

Exponential growth in brain tumor molecular information. Pubmed search results for the combined terms “brain tumor” and “molecular” from 1979 to 2017. Annotations show the year of identification for key molecular features that were incorporated into the WHO 2016 diagnostic recommendations, including 1p/19q-codeletion for oligodendroglioma (1p/19q), loss of INI1 protein for atypical teratoid/rhabdoid tumor (INI1), isocitrate dehydrogenase alterations for lower grade infiltrating gliomas (IDH), histone H3 mutations for diffuse midline and other pediatric high-grade gliomas (H3.3/H3.1), RELA fusions for supratentorial ependymoma (RELA), and chromosome 19 microRNA cluster alterations for embryonal tumor with multilayered rosettes (C19MC)

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Diagnostic Pathology

ISSN: 1746-1596

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