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Table 2 Analysis of risk factors for HER-2 positivity

From: A nomogram for predicting the HER2 status in female patients with breast cancer in China: a nationwide, multicenter, 10-year epidemiological study

 

Univariate analysis

Multivariate analysis

OR (95% CI)

P

OR (95% CI)

P

Age

0.994 (0.984–1.005)

0.297

  

BMI

0.995 (0.960–1.031)

0.769

  

Location of Lesions

 UOQ

1

   

 UIQ

1.094 (0.813–1.471)

0.554

  

 LIQ

1.030 (0.645–1.646)

0.900

  

 LOQ

0.822 (0.561–1.204)

0.313

  

 Central

0.600 (0.411–0.877)

0.008

  

 N/A

1.100 (0.701–1.725)

0.679

  

T-Stage

 T1

1

 

1

 

 T2

0.787 (0.621–0.998)

0.048

0.720 (0.562–0.921)

0.009

 T3

0.767 (0.492–1.196)

0.242

0.623 (0.392–0.989)

0.045

 T4

0.607 (0.322–1.145)

0.123

0.493 (0.256–0.949)

0.034

Local Infiltration

 No

1

   

 Only Skin

0.761 (0.388–1.492)

0.426

  

 Only Chest Wall

0.830 (0.172–4.012)

0.817

  

 Skin & Chest Wall

0.000

0.999

  

N-Stage

 N0

1

 

1

 

 N1

1.165 (0.895–1.517)

0.256

1.172 (0.892–1.540)

0.255

 N2

1.830 (1.249–2.681)

0.002

1.747 (1.182–2.583)

0.005

 N3

2.605 (1.559–4.351)

0.000

2.866 (1.683–4.879)

0.000

Histology

 CIS-Mi

1

 

1

 

 IDC

0.990(0.518–1.890)

0.975

0.919(0.475–1.777)

0.801

 ILC

0.367(0.127–1.064)

0.065

0.379(0.129–1.110)

0.077

 Others

0.337(0.143–0.794)

0.013

0.296(0.124–0.710)

0.006

ER

 Negative

1

 

1

 

 Positive

0.591(0.475–0.736)

0.000

0.690(0.522–0.914)

0.010

PR

 Negative

1

 

1

 

 Positive

0.602(0.483–0.750)

0.000

0.726(0.548–0.961)

0.025

  1. Logistic regression analysis was used for univariate and multivariate analysis of different variables predicting HER2 positivity