Fig. 1

First renal cancer. a Tumor composed of solid sheets of uniform cells with granular eosinophilic cytoplasm intermixed with cells displaying a clearer cytoplasm. Entrapped tubules are identified at the periphery of the neoplasm (HE × 200). b Tumor cells display round and uniform nuclei. (HE × 400). c Tumor cells are positive for SDHB (SDHB × 200). d Note the granular positivity for SDHB immunohistochemistry in a cytoplasmic mitochondrial pattern. Non-tumor entrapped tubules show a stronger positivity for SDHB than tumor cells, arrowhead (SDHB × 400)