Updated Oxford classification and the international study of kidney disease in children classification: application in predicting outcome of Henoch-Schönlein purpura nephritis

Table 2 Detailed pathologic features for patients with or without renal endpoints

Pathologic features	Renal endpoints reached		P value
Pathologic features	Yes	No	P value
Mesangial hypercellularity ^a, n (%)			0.238
Normal	0	2 (0.4)
Mild	26 (86.7)	207 (84.5)
Moderate	3 (10.0)	35 (14.3)
Severe	1 (3.3)	1 (0.4)
tubulointerstitial inflammation ^a,b, n (%)			0.004
Absent	4 (13.3)	68 (27.7)
≤25%	12 (40.0)	133 (54.3)
>25% and ≤ 50%	6 (20.0)	12 (4.9)
>50%	8 (26.7)	32 (13.1)
Proportion of glomeruli per biopsy
Segmental sclerosis (%)^c	3.4 (0, 16.7)	2.0 (0, 7.5)	0.098
Crescents (%)^c	12.9 (3.5, 23.3)	4.0 (0, 13.3)	<0.001
Tubular atrophy (%)^c	5 (1, 15)	5 (0, 5)	0.013

The data was expressed as numbers (percentages)
^aMesangial hypercellularity was assessed in semi- quantitative way: normal = 3 or less cells per mesangial area; mild = 4 or 5 cells per mesangial area; moderate = 6 or 7 cells per mesangial area; severe = 8 or more cells in mesangial area
^bTubulointerstitial inflammation applied to inflammation in the biopsy overall (including areas of interstitial fibrosis/tubular atrophy)
^cProportion of glomeruli per biopsy with lesion, data was expressed as median (interquartile range)

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