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Table 1 p16/Ki-67 study results and CIN2+ outcome for three cytopathology laboratories and references

From: Interobserver variability and accuracy of p16/Ki-67 dual immunocytochemical staining on conventional cervical smears

Reviewer Categories of p16/Ki-67 dual staining result Initial training Additional training
p16/Ki-67 dual staining result N (%)a CIN2+ outcome N (PV, %)b p16/Ki-67 dual staining result N (%)a CIN2+ outcome N (PV, %)b
LAB1 positive 60 (46.5) 46 (76.7) 72 (55.8) 57 (79.2)
suspicious 10 (7.8) 6 (60.0) 1 (0.8) 0 (0.0)
negative 58 (45.0) 11 (19.0) 56 (43.4) 6 (10.7)
unsatisfactory 1 (0.8) 0 (0.0) 0 (0.0) 0 (0.0)
LAB2 positive 67 (51.9) 51 (76.1) 74 (57.4) 56 (75.7)
suspicious 14 (10.9) 6 (42.9) 3 (2.3) 0 (0.0)
negative 40 (31.0) 6 (15.0) 52 (40.3) 7 (13.5)
unsatisfactory 8 (6.2) 0 (0.0) 0 (0.0) 0 (0.0)
LAB3 positive 49 (38.0) 38 (77.6) 68 (52.7) 53 (77.9)
suspicious 17 (13.2) 12 (70.6) 2 (1.6) 1 (50.0)
negative 63 (48.8) 13 (20.6) 58 (45.0) 9 (15.5)
unsatisfactory 0 (0.0) 0 (0.0) 1 (0.8) 0 (0.0)
Reference1 positive 60 (46.5) 49 (81.7)   
suspicious 12 (9.3) 5 (41.7)   
negative 57 (44.2) 9 (15.8)   
unsatisfactory 0 (0.0) 0 (0.0)   
Reference2 positive    74 (57.4) 56 (75.7)
suspicious    1 (0.8) 0 (0.0)
negative    54 (41.9) 7 (13.0)
unsatisfactory    0 (0.0) 0 (0.0)
  1. LAB1 … Laboratory1, LAB2 … Laboratory2, LAB3 … Laboratory3, Reference1 … consensus of 5 cytopathologists, Reference2 … consensus obtained during discussion between participants and expert
  2. aConsensus results within each laboratory/reference (n = 129)
  3. bPV...predictive value (number of CIN2 + detected within specific category of p16/Ki-67 dual staining result divided by the number of test results in specific category)