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Table 1 p16/Ki-67 study results and CIN2+ outcome for three cytopathology laboratories and references

From: Interobserver variability and accuracy of p16/Ki-67 dual immunocytochemical staining on conventional cervical smears

Reviewer

Categories of p16/Ki-67 dual staining result

Initial training

Additional training

p16/Ki-67 dual staining result N (%)a

CIN2+ outcome N (PV, %)b

p16/Ki-67 dual staining result N (%)a

CIN2+ outcome N (PV, %)b

LAB1

positive

60 (46.5)

46 (76.7)

72 (55.8)

57 (79.2)

suspicious

10 (7.8)

6 (60.0)

1 (0.8)

0 (0.0)

negative

58 (45.0)

11 (19.0)

56 (43.4)

6 (10.7)

unsatisfactory

1 (0.8)

0 (0.0)

0 (0.0)

0 (0.0)

LAB2

positive

67 (51.9)

51 (76.1)

74 (57.4)

56 (75.7)

suspicious

14 (10.9)

6 (42.9)

3 (2.3)

0 (0.0)

negative

40 (31.0)

6 (15.0)

52 (40.3)

7 (13.5)

unsatisfactory

8 (6.2)

0 (0.0)

0 (0.0)

0 (0.0)

LAB3

positive

49 (38.0)

38 (77.6)

68 (52.7)

53 (77.9)

suspicious

17 (13.2)

12 (70.6)

2 (1.6)

1 (50.0)

negative

63 (48.8)

13 (20.6)

58 (45.0)

9 (15.5)

unsatisfactory

0 (0.0)

0 (0.0)

1 (0.8)

0 (0.0)

Reference1

positive

60 (46.5)

49 (81.7)

  

suspicious

12 (9.3)

5 (41.7)

  

negative

57 (44.2)

9 (15.8)

  

unsatisfactory

0 (0.0)

0 (0.0)

  

Reference2

positive

  

74 (57.4)

56 (75.7)

suspicious

  

1 (0.8)

0 (0.0)

negative

  

54 (41.9)

7 (13.0)

unsatisfactory

  

0 (0.0)

0 (0.0)

  1. LAB1 … Laboratory1, LAB2 … Laboratory2, LAB3 … Laboratory3, Reference1 … consensus of 5 cytopathologists, Reference2 … consensus obtained during discussion between participants and expert
  2. aConsensus results within each laboratory/reference (n = 129)
  3. bPV...predictive value (number of CIN2 + detected within specific category of p16/Ki-67 dual staining result divided by the number of test results in specific category)