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Table 3 Characteristics of p16/Ki-67 dual staining in suspicious and positive recordings

From: Interobserver variability and accuracy of p16/Ki-67 dual immunocytochemical staining on conventional cervical smears

p16/Ki-67 staining characteristics p16/Ki-67 result p-value
positive suspicious
N % N %
Number of stained cells 1 57 16.1 36 45.0 0.000
2 31 8.8 18 22.5
3 37 10.5 13 16.3
4 17 4.8 5 6.3
5 211 59.8 8 10.0
p16 staining intensity appropriate 238 82.6 35 63.6 0.001
weak 50 17.4 20 36.4
Ki-67 staining intensity appropriate 273 94.8 53 96.4 1.000
weak 15 5.2 2 3.6
Cell morphology preserved 285 99.3 51 92.7 0.007
less preserved 2 0.7 4 7.3
Counter stain appropriate 284 99.0 52 94.5 0.055
weak 3 1.0 3 5.5
Background staining not present/ weak 252 88.1 43 78.2 0.048
strong 34 11.9 12 21.8
  1. Table includes staining characteristics from positive and suspicious readings recorded by all participants before additional training. Some results had missing data on staining characteristics, therefore sums for individual characteristics differ