Table 1 Patients’ characteristics and treatment outcomes in 43 adult patients with PCNSL
Factor | ORR N (%) | P | CR N (%) | P | Median RFS (Mo) | P | Median OS (Mo) | P |
|---|---|---|---|---|---|---|---|---|
Age (years) | ||||||||
- < 60 | 10/12 (83) | 0.966 | 4/12 (33) | 0.065 | NR | 0.837 | 15 | 0.347 |
- ≥ 60 | 26/31 (84) | 20/31 (65) | NR | 17 | ||||
ECOG score | ||||||||
- 0–2 | 18/20 (90) | 0.298 | 15/20 (75) | 0.018 | NR | 0.820 | NR | 0.001 |
- 3–4 | 18/23 (78) | 9/23 (39) | NR | 13 | ||||
Brain lesion | ||||||||
- Single | 13/16 (81) | 0.735 | 5/16 (31) | 0.013 | NR | 0.456 | 9 | 0.010 |
- Multiple (≥ 2) | 23/27 (85) | 19/27 (70) | NR | 26 | ||||
Area of brain involvement | ||||||||
- Single | 12/15 (80) | 0.629 | 4/15 (27) | 0.005 | NR | 0.900 | 10 | 0.023 |
- Multiple (≥ 2) | 24/28 (86) | 20/28 (71) | NR | 26 | ||||
Deep structure involvement | ||||||||
- Yes | 25/31 (81) | 0.380 | 18/31 (58) | 0.633 | NR | 0.141 | 26 | 0.203 |
- No | 11/12 (92) | 6/12 (50) | 10 | 12 | ||||
Maximum tumor size | ||||||||
- < 3 cm | 14/17 (82) | 0.844 | 10/17 (59) | 0.748 | NR | 0.850 | NR | 0.103 |
- ≥ 3 cm | 22/26 (85) | 14/26 (54) | NR | 13 | ||||
Maximum tumor size | ||||||||
- < 5 cm | 29/33 (88) | 0.180 | 20/33 (61) | 0.250 | NR | 0.217 | 26 | 0.004 |
- ≥ 5 cm | 7/10 (70) | 4/10 (40) | 7 | 8 | ||||
Treatment | ||||||||
- Chemotherapy (CMT) | 12/14 (86) | 0.028 | 5/14 (36) | 0.056 | NR | 0.663 | 17 | 0.259 |
- Radiotherapy (RT) | 5/9 (56) | 4/9 (44) | NR | 13 | ||||
- CMT + RT | 19/20 (95) | 15/20 (75) | NR | NR | ||||
Treatment | ||||||||
- CMT + RT | 19/20 (95) | 0.062 | 15/20 (75) | 0.018 | NR | 0.845 | NR | 0.231 |
- Single therapy (CMT or RT) | 17/23 (74) | 9/23 (39) | NR | 14 | ||||
LDH | ||||||||
- Normal | 22/25 (88) | 0.681 | 16/25 (64) | 0.544 | NR | 0.788 | 17 | 0.876 |
- High | 12/13 (92) | 7/13 (54) | NR | 15 | ||||