Fig. 2

Histopathology of the tonsillar mass characteristic of HVCD (hematoxylin-eosin (H&E) staining). a (5× and 40× H&E): Photomicrographs showing lymphoid tissue with follicular hyperplasia, which was composed of lymphoid follicles of variable size and shape. These distinctive follicles had atrophic hyalinized germinal centers and a broad mantle zone. Increased numbers of thickened and hyalinized venules were observed in the center of lymphatic follicles and mantle zones. b (5× and 40× H&E): Many hyalinized venules in the interfollicular areas. c (10× and 40×, H&E) and d (5× and 40×, H&E): Germinal center atrophy even tended to disappear, and some areas were penetrated by small hyalinized vessels. e (5×, H&E): Lymphoid follicles with an expended mantle zone (onion-skin arrangement). f (5×, H&E): A characteristic lollipop appearance was observed (the onion-skin arrangement with a vessel penetrating the germinal center)