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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Hyaline vascular variant of unicentric Castleman disease of the tonsil: a case report

Fig. 3

Immunohistochemical (IHC) features and in situ hybridization (ISH) results. a and b (5×, IHC): Follicular dendritic cells stained with CD21 and CD23 antibodies. c and d (5×, IHC): T-cells stained with CD3 and CD5 antibodies. e and f (5×, IHC): B-cells stained with CD20 and CD79α antibodies. g (5×, IHC) and h (20×, IHC): Bcl-2 staining indicated small and mature lymphocytes in the mantle zone and T-cells in the interfollicular areas. i (20×, IHC): The small lymphocytes in the expended mantle zone were negative for cyclin D1. j (10×, IHC): Ki-67 staining indicated proliferating cells, which were mainly observed in the germinal centers. k (10×, IHC): Immunostaining with HHV-8 was negative. l (10×, ISH): EBER-ISH to detect EBV was negative

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