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Table 4 Accuracy for all readers and observation methods

From: Validation of mitotic cell quantification via microscopy and multiple whole-slide scanners

 

Scanner A

Scanner B

Scanner C

Scanner D

Microscope

Observer.1

0.713

0.743

0.685

0.706

0.764

Observer.2

0.700

0.715

0.631

0.648

0.778

Observer.3

0.704

0.738

0.717

0.802

0.806

Observer.4

0.691

0.726

0.699

0.717

0.842

Observer.5

0.698

0.754

0.738

0.785

0.802

Average

0.701

0.735

0.694

0.732

0.798

SE

0.021

0.023

0.028

0.035

0.021

95% CI

(0.659, 0.743)

(0.689, 0.780)

(0.636, 0.752)

(0.653, 0.810)

(0.754, 0.842)

p-value

0.001*

0.009*

0.001*

0.062

 
  1. Accuracy refers to the average of sensitivity and specificity. SE, standard error; CI, confidence interval. The p-value corresponds to a two-sided hypothesis test comparing reader-averaged accuracy with each scanner viewing mode to the accuracy of the microscope. The p-values of the four hypotheses are compared following the sequentially rejective Bonferroni test with alpha = 0.05 [33]. Statistical significance is indicated with an asterisk *. All analyses account for the correlations and variability from the readers reading the same ROIs, and the correlations arising from MFs contained within the same slides
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Diagnostic Pathology

ISSN: 1746-1596

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