Table 1 Comparison of clinicopathological characteristics between EGFR mutation and EGFR wild-type cases with SqCC or NSCC favor SqCC diagnosed from small biopsies
Characteristics | Total | EGFR mutation | EGFR wild-type | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
No. | % | No. | % | No. | % | |||||
Number | 148 | 100.0 (148/148) | 13 | 100.0 (13/13) | 135 | 100.0 (135/135) | Â | Â | Â | Â |
Age(y) | P = 0.527 | P = 0.810 | ||||||||
 Median | 70.2 ± 12.4 | 67.5 ± 16.0 | 70.4 ± 12.1 |  |  |  |  | |||
 Range | 41–93 | 44–86 | 41–93 |  |  |  |  | |||
Sex | P = 0.039* | P = 0.841 | ||||||||
 Male | 78 | 52.7 (78/148) | 3 | 23.1 (3/13) | 75 | 55.6 (75/135) |  |  |  |  |
 Female | 70 | 47.3 (70/148) | 10 | 76.9 (10/13) | 60 | 44.4 (60/135) |  |  |  |  |
Smoking status | P < 0.0001* | P = 0.006* | ||||||||
 Never smoker | 39 | 30.5 (39/128) | 10 | 83.3 (10/12) | 29 | 25.0 (29/116) |  |  |  |  |
 Smoker | 89 | 69.5 (89/128) | 2 | 16.7 (2/12) | 87 | 75.0 (87/116) |  |  |  |  |
 Unknown | 20 |  | 1 |  | 19 |  |  |  |  |  |
Biopsy method | P = 0.826 |  |  | |||||||
 Bronchoscopic | 72 | 56.7 (72/127) | 6 | 50.0 (6/12) | 66 | 57.4 (66/115) |  |  |  |  |
 CT-guided | 40 | 31.5 (40/127) | 4 | 33.3 (4/12) | 36 | 31.3 (36/115) |  |  |  |  |
 Sono-guided | 15 | 11.8 (15/127) | 2 | 16.7 (2/12) | 13 | 11.3 (13/115) |  |  |  |  |
 Unknown | 21 |  | 1 |  | 20 |  |  |  |  |  |
Biopsy tissue | ||||||||||
 Average pieces | 4.4 ± 2.0 | 4.4 ± 2.2 | 4.4 ± 2.0 | P = 0.925 |  |  | ||||
 Mean size (mm) | 6.6 ± 4.0 | 6.6 ± 3.3 | 6.6 ± 4.0 | P = 0.964 |  |  | ||||
Histological subtype | P < 0.0001* | P = 0.001* | ||||||||
 SqCC | 135 | 91.2 (135/148) | 7 | 53.8 (7/13) | 128 | 94.8 (128/135) |  |  |  |  |
 NSCC favor SqCC | 13 | 8.8 (13/148) | 6 | 46.2 (6/13) | 7 | 5.2 (7/135) |  |  |  |  |