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Table 1 Comparison of clinicopathological characteristics between EGFR mutation and EGFR wild-type cases with SqCC or NSCC favor SqCC diagnosed from small biopsies

From: The importance of EGFR mutation testing in squamous cell carcinoma or non-small cell carcinoma favor squamous cell carcinoma diagnosed from small lung biopsies

Characteristics Total EGFR mutation EGFR wild-type Univariate analysis Multivariate analysis
No. % No. % No. %
Number 148 100.0 (148/148) 13 100.0 (13/13) 135 100.0 (135/135)     
Age(y) P = 0.527 P = 0.810
 Median 70.2 ± 12.4 67.5 ± 16.0 70.4 ± 12.1     
 Range 41–93 44–86 41–93     
Sex P = 0.039* P = 0.841
 Male 78 52.7 (78/148) 3 23.1 (3/13) 75 55.6 (75/135)     
 Female 70 47.3 (70/148) 10 76.9 (10/13) 60 44.4 (60/135)     
Smoking status P < 0.0001* P = 0.006*
 Never smoker 39 30.5 (39/128) 10 83.3 (10/12) 29 25.0 (29/116)     
 Smoker 89 69.5 (89/128) 2 16.7 (2/12) 87 75.0 (87/116)     
 Unknown 20   1   19      
Biopsy method P = 0.826   
 Bronchoscopic 72 56.7 (72/127) 6 50.0 (6/12) 66 57.4 (66/115)     
 CT-guided 40 31.5 (40/127) 4 33.3 (4/12) 36 31.3 (36/115)     
 Sono-guided 15 11.8 (15/127) 2 16.7 (2/12) 13 11.3 (13/115)     
 Unknown 21   1   20      
Biopsy tissue
 Average pieces 4.4 ± 2.0 4.4 ± 2.2 4.4 ± 2.0 P = 0.925   
 Mean size (mm) 6.6 ± 4.0 6.6 ± 3.3 6.6 ± 4.0 P = 0.964   
Histological subtype P < 0.0001* P = 0.001*
 SqCC 135 91.2 (135/148) 7 53.8 (7/13) 128 94.8 (128/135)     
 NSCC favor SqCC 13 8.8 (13/148) 6 46.2 (6/13) 7 5.2 (7/135)     
  1. *Statistically significant