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Fig. 4 | Diagnostic Pathology

Fig. 4

From: BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia

Fig. 4

Molecular signatures associated with BCL2 in AML from TCGA cohort. a: Expression heatmap of differentially expressed genes between BCL2low and BCL2high AML patients among TCGA datasets (FDR < 0.05, P < 0.05 and |log2 FC| > 1). b: Volcano plot of differentially expressed genes between BCL2low and BCL2high AML patients. c: Gene Ontology analysis of DEGs conducted using online website of STRING (http://string-db.org). d: Expression heatmap of differentially expressed microRNAs between BCL2low and BCL2high AML patients among TCGA datasets (FDR < 0.05, P < 0.05 and |log2 FC| > 1). e: Venn results of microRNAs which could target BCL2 predicted by TargetScan (http://www.targetscan.org/vert_72/), mirDIP (http://ophid.utoronto.ca/mirDIP/), miRWalk (http://mirwalk.umm.uni-heidelberg.de/), and miRDB (http://mirdb.org/miRDB/)

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