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Table 2 Clinical features and treatment patterns of 11 patients double mutations

From: Relevance and clinicopathologic relationship of BRAF V600E, TERT and NRAS mutations for papillary thyroid carcinoma patients in Northwest China

No Sex Age Blood type BMI Surgery Operation time (min) Invasion Lesion location Lesion number Pathology Stage LNM LNM location Gene mutation 131I
1 F 29 O 27.5 a 100 Yes Bilateral Multiple PTC + HT mpT1bN1 1/1 lateral cervical LN BRAF p.V600E(c.1800 T > A) (Ct = 18.31),
NRAS Exon2 G12D/G12S (Ct = 21.88)
Yes
2 F 62 AB 24.4 a 60 Yes Bilateral Multiple PTMC T1a(3)N1a 1/4 Central LN BRAF p.V600E (Ct = 19.46),
NRAS Exon2 G12D/G12S (Ct = 24.5)
Yes
3 F 69 O 24.6 a 60 Yes Bilateral Multiple PTC T1b(m)N1b 11/15 Prelaryngeal and lateral cervical LN BRAF p.V600E(c.1799 T > A) (Ct = 19.07),
NRAS Exon3 Q61X (Ct = 26.57)
Yes
4 F 54 B 24.8 a 120 No Bilateral Multiple PTC T1bNx 1/2 Central LN BRAF p.V600E) (Ct = 18.34),
NRAS Exon3 Q61X (Ct = 24.03)
Yes
5 M 56 B 27.5 a 80 Yes Unilateral Single PTC + HT T1aN0 No No BRAF p.V600E(c.1800 T > A) (Ct = 18.03),
TERT C228T
Yes
6 F 42 B 22.9 a 70 Yes Unilateral Single PTC T1bN1a 1/4 Central LN BRAF p.V600E(Ct = 17.12),
TERT C228T
Yes
7 F 66 A 27.1 a 180 Yes Unilateral Multiple PTC T3b(2) N1 1/12 lateral cervical LN BRAF p.V600E(Ct = 19.11),
TERT C228T,C250T
Yes
8 F 56 AB 23.0 b 85 No Unilateral Single PTMC T1aN1a 1/2 Central LN BRAF p.V600E(Ct = 17.84),
TERT C228T
No
9 F 62 B 23.4 a 160 Yes Bilateral Multiple PTMC T1a(2)N1 6/24 Central and lateral cervical LN BRAF p.V600E(Ct = 18.7),
TERT C228T
Yes
10 F 46 B 23.9 a 150 Yes Unilateral Multiple PTC T2 N1 7/16 Central and lateral cervical LN BRAF p.V600E(Ct = 18.45),
TERT C228T
Yes
11 F 58 A 28.8 a 60 No Bilateral Multiple PTC T1b(2)Nx No No BRAF p.V600E(Ct = 18.72),
TERT C228T
Yes
12 F 60 A 24.17 a 105 No Unilateral Single PTMC T1aN0 No No BRAF p.V600E (Ct = 17.7),
NRAS Exon2 G12X/G13X (Ct = 23.8)
No
13 F 56 B 25.08 a 160 Yes Unilateral Multiple PTC T1bN0 No No BRAF p.V600E(Ct = 19.78),
TERT C228T
No
14 F 43 A 27.05 b 75 No Unilateral Single PTMC T1aN0 No No BRAF p.V600E (Ct = 19.73),
NRAS Exon3 Q61X (Ct = 24.57)
No
15 M 72 B 22.84 a 155 Yes Unilateral Single PTC T2 N1b 4/4 lateral cervical LN BRAF p.V600E(Ct = 17.51),
TERT C228T
Yes
16 F 67 O 29.07 b 80 No Unilateral Single PTMC T1aN0 No No BRAF p.V600E(Ct = 20.47),
TERT C228T
No
  1. a total thyroidectomy, b near-total thyroidectomy, PTC Papillary thyroid cancer, PTMC Papillary thyroid microcarcinoma, HT Hashimoto thyroiditis, LNM Lymph node metastasis