Table 2 Clinical features and treatment patterns of 11 patients double mutations
| No | Sex | Age | Blood type | BMI | Surgery | Operation time (min) | Invasion | Lesion location | Lesion number | Pathology | Stage | LNM | LNM location | Gene mutation | 131I |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 29 | O | 27.5 | a | 100 | Yes | Bilateral | Multiple | PTC + HT | mpT1bN1 | 1/1 | lateral cervical LN |
BRAF p.V600E(c.1800 T > A) (Ct = 18.31), NRAS Exon2 G12D/G12S (Ct = 21.88) | Yes |
| 2 | F | 62 | AB | 24.4 | a | 60 | Yes | Bilateral | Multiple | PTMC | T1a(3)N1a | 1/4 | Central LN |
BRAF p.V600E (Ct = 19.46), NRAS Exon2 G12D/G12S (Ct = 24.5) | Yes |
| 3 | F | 69 | O | 24.6 | a | 60 | Yes | Bilateral | Multiple | PTC | T1b(m)N1b | 11/15 | Prelaryngeal and lateral cervical LN |
BRAF p.V600E(c.1799 T > A) (Ct = 19.07), NRAS Exon3 Q61X (Ct = 26.57) | Yes |
| 4 | F | 54 | B | 24.8 | a | 120 | No | Bilateral | Multiple | PTC | T1bNx | 1/2 | Central LN |
BRAF p.V600E) (Ct = 18.34), NRAS Exon3 Q61X (Ct = 24.03) | Yes |
| 5 | M | 56 | B | 27.5 | a | 80 | Yes | Unilateral | Single | PTC + HT | T1aN0 | No | No |
BRAF p.V600E(c.1800 T > A) (Ct = 18.03), TERT C228T | Yes |
| 6 | F | 42 | B | 22.9 | a | 70 | Yes | Unilateral | Single | PTC | T1bN1a | 1/4 | Central LN |
BRAF p.V600E(Ct = 17.12), TERT C228T | Yes |
| 7 | F | 66 | A | 27.1 | a | 180 | Yes | Unilateral | Multiple | PTC | T3b(2) N1 | 1/12 | lateral cervical LN |
BRAF p.V600E(Ct = 19.11), TERT C228T,C250T | Yes |
| 8 | F | 56 | AB | 23.0 | b | 85 | No | Unilateral | Single | PTMC | T1aN1a | 1/2 | Central LN |
BRAF p.V600E(Ct = 17.84), TERT C228T | No |
| 9 | F | 62 | B | 23.4 | a | 160 | Yes | Bilateral | Multiple | PTMC | T1a(2)N1 | 6/24 | Central and lateral cervical LN |
BRAF p.V600E(Ct = 18.7), TERT C228T | Yes |
| 10 | F | 46 | B | 23.9 | a | 150 | Yes | Unilateral | Multiple | PTC | T2 N1 | 7/16 | Central and lateral cervical LN |
BRAF p.V600E(Ct = 18.45), TERT C228T | Yes |
| 11 | F | 58 | A | 28.8 | a | 60 | No | Bilateral | Multiple | PTC | T1b(2)Nx | No | No |
BRAF p.V600E(Ct = 18.72), TERT C228T | Yes |
| 12 | F | 60 | A | 24.17 | a | 105 | No | Unilateral | Single | PTMC | T1aN0 | No | No |
BRAF p.V600E (Ct = 17.7), NRAS Exon2 G12X/G13X (Ct = 23.8) | No |
| 13 | F | 56 | B | 25.08 | a | 160 | Yes | Unilateral | Multiple | PTC | T1bN0 | No | No |
BRAF p.V600E(Ct = 19.78), TERT C228T | No |
| 14 | F | 43 | A | 27.05 | b | 75 | No | Unilateral | Single | PTMC | T1aN0 | No | No |
BRAF p.V600E (Ct = 19.73), NRAS Exon3 Q61X (Ct = 24.57) | No |
| 15 | M | 72 | B | 22.84 | a | 155 | Yes | Unilateral | Single | PTC | T2 N1b | 4/4 | lateral cervical LN |
BRAF p.V600E(Ct = 17.51), TERT C228T | Yes |
| 16 | F | 67 | O | 29.07 | b | 80 | No | Unilateral | Single | PTMC | T1aN0 | No | No |
BRAF p.V600E(Ct = 20.47), TERT C228T | No |