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Table 3 Relationship between gene mutations and clinicopathologic features of PTC

From: Relevance and clinicopathologic relationship of BRAF V600E, TERT and NRAS mutations for papillary thyroid carcinoma patients in Northwest China

  No gene mutation
(N = 48)
BRAF V600E mutation alone(N = 419) Double mutations
(N = 16)
χ 2 /F P
Sex
 Male 13 (27.1%) 112 (26.7%) 2 (12.5%) 1.627 0.443
 Female 35 (72.9%) 307 (73.3%) 14 (87.5%)
Average age 37.9 ± 12.6 43.2 ± 10.7 56.0 ± 11.0 16.704 < 0.001
Average BMI 22.8 ± 3.57 24.9 ± 5.08 25.38 ± 2.06 3.521 0.316
Pathology
 PTC 23 (47.9%) 154 (36.8%) 10 (62.5%) 6.207 0.045
 PTMC 25 (52.1%) 265 (63.2%) 6(37.5%)
Lesion number
 Single lesion 38 (79.2%) 293(69.9%) 7 (43.8%) 7.169 0.028
 Multiple lesions 10 (20.8%) 126(30.1%) 9 (56.2%)
Lesion location
 Unilateral 38 (79.2%) 353 (84.2%) 9 (56.2%) 8.988 0.011
 Bilateral 10 (20.8%) 66 (15.8%) 7(43.8%)
Surgery
 Total thyroidectomy 39 (81.3%) 332 (79.2%) 13 (81.3%) 0.138 0.933
 Near-total thyroidectomy 9 (18.7%) 87(20.8%) 3 (18.7%)
LNM
 Yes 31 (64.6%) 180 (43.0%) 10 (62.5%) 9.983 0.007
 No 17 (35.4%) 239 (57.0%) 6(37.5%)
131I radiotherapy
 Yes 24 (50.0%) 163(38.9%) 11 (68.8%) 7.463 0.024
 No 24 (50.0%) 256 (61.1%) 5 (31.2%)