Table 3 Relationship between gene mutations and clinicopathologic features of PTC
No gene mutation (N = 48) | BRAF V600E mutation alone(N = 419) | Double mutations (N = 16) | χ 2 /F | P | |
|---|---|---|---|---|---|
Sex | |||||
Male | 13 (27.1%) | 112 (26.7%) | 2 (12.5%) | 1.627 | 0.443 |
Female | 35 (72.9%) | 307 (73.3%) | 14 (87.5%) | ||
Average age | 37.9 ± 12.6 | 43.2 ± 10.7 | 56.0 ± 11.0 | 16.704 | < 0.001 |
Average BMI | 22.8 ± 3.57 | 24.9 ± 5.08 | 25.38 ± 2.06 | 3.521 | 0.316 |
Pathology | |||||
PTC | 23 (47.9%) | 154 (36.8%) | 10 (62.5%) | 6.207 | 0.045 |
PTMC | 25 (52.1%) | 265 (63.2%) | 6(37.5%) | ||
Lesion number | |||||
Single lesion | 38 (79.2%) | 293(69.9%) | 7 (43.8%) | 7.169 | 0.028 |
Multiple lesions | 10 (20.8%) | 126(30.1%) | 9 (56.2%) | ||
Lesion location | |||||
Unilateral | 38 (79.2%) | 353 (84.2%) | 9 (56.2%) | 8.988 | 0.011 |
Bilateral | 10 (20.8%) | 66 (15.8%) | 7(43.8%) | ||
Surgery | |||||
Total thyroidectomy | 39 (81.3%) | 332 (79.2%) | 13 (81.3%) | 0.138 | 0.933 |
Near-total thyroidectomy | 9 (18.7%) | 87(20.8%) | 3 (18.7%) | ||
LNM | |||||
Yes | 31 (64.6%) | 180 (43.0%) | 10 (62.5%) | 9.983 | 0.007 |
No | 17 (35.4%) | 239 (57.0%) | 6(37.5%) | ||
131I radiotherapy | |||||
Yes | 24 (50.0%) | 163(38.9%) | 11 (68.8%) | 7.463 | 0.024 |
No | 24 (50.0%) | 256 (61.1%) | 5 (31.2%) | ||