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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Primary endocervical gastric-type adenocarcinoma: a clinicopathologic and immunohistochemical analysis of 23 cases

Fig. 2

a Gross feature of gastric-type adenocarcinoma (GAS). The cervix was partially or entirely replaced by a firm indurated mass imparting a barrel-shaped enlargement. b-c, Well-differentiated GAS showed haphazardly arranged and irregularly shaped neoplastic glands, which were usually associated with a desmoplastic stromal reaction. The cells showed voluminous, clear to foamy cytoplasm and distinct cellular borders (H&E, 100×). d Moderately or poorly differentiated GAS showed extensive epithelial proliferation with crowded, back-to-back glands (H&E, 40×). e A GAS showed an area with voluminous clear cytoplasm and round, markedly atypical nuclei (H&E, 100×). f Uniform mucinous cells showed minimal or no cytological atypia (H&E, 40×). g A GAS case showed mild to moderate nuclear enlargement and pseudostratification (H&E, 200×). h-i, Bland-appearing mucinous epithelium replaced the fallopian tube normal epithelium and was composed of columnar cells with basally located small nuclei, without distinct nuclear abnormalities (H&E, 100×,200×)

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