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Table 1 The relationship between MYC, BCL2 and BCL6 genetic alterations and protein expression

From: Prognostic impact of diffuse large B-cell lymphoma with extra copies of MYC, BCL2 and/or BCL6: comparison with double/triple hit lymphoma and double expressor lymphoma

  MYC + P BCL2 + P BCL6 + P MYC/BCL2 + P GCB non-GCB P
MYC normal 42(40.8)   76(73.8)   73(70.9)   36(35.0)   39(37.9) 64(62.1)  
MYC EC 8(57.1) 0.245 11(78.6) > 0.999* 10(71.4) > 0.999* 6(42.9) 0.563 6(42.9) 8(57.1) 0.719
MYC R 11(84.6) 0.006* 11(84.6) 0.513* 8(61.5) 0.528 9(69.2) 0.031* 5(38.5) 8(61.5) 0.967
MYC EC VS R   0.209*   > 0.999*   0.695*   0.252*    0.816
BCL2 normal 36(40.9)   59(67.0)   62(70.5)   26(29.5)   34(38.6) 54(61.4)  
BCL2 EC 16(61.5) 0.064 24(92.3) 0.011* 17(65.4) 0.622 16(61.5) 0.003 7(26.9) 19(73.1) 0.274
BCL2 R 12(63.2) 0.077 18(94.7) 0.021* 15(78.9) 0.579* 12(63.2) 0.005 11(57.9) 8(42.1) 0.123
BCL2 EC VS R   0.987   > 0.999*   0.495*   0.987    0.027
BCL6 normal 40(43.5)   69(75.0)   62(67.4)   33(35.9)   35(38.0) 57(62.0)  
BCL6 EC 12(63.2) 0.118 16(84.2) 0.555* 13(68.4) 0.930 11(57.9) 0.074 7(36.8) 12(63.2) 0.922
BCL6 R 11(50.0) 0.580 16(72.7) 0.826 19(86.4) 0.115* 9(40.9) 0.660 10(45.5) 12(54.5) 0.523
BCL6 EC VS R 11(64.7) 0.296 14(82.4) 0.451* 11(64.7) 0.255* 10(58.8) 0.187 6(35.3) 11(64.7) 0.676
Conventional DLBCL 23(37.1)   42(67.7)   44(71.0)   18(29.0)   26(41.9) 36(58.1)  
Atypical DHL/THL 8(66.7) 0.107* 10(83.3) 0.491* 9(75.0) > 0.999* 7(58.3) 0.049 6(50.0) 6(50.0) 0.606
DHL/THL 8(80.0) 0.016* 9(90.0) 0.262* 8(80.0) 0.716* 7(70.0) 0.027* 5(50.0) 5(50.0) 0.633
Atypical DHL/THL VS DHL/THL   0.646*   > 0.999*   > 0.999*   0.675*    > 0.999*
DEL + 37(100.0) < 0.001* 37(100.0) < 0.001* 25(67.6) 0.878 37(100.0) < 0.001* 10(27.0) 27(73.0) 0.156
DEL - 8(11.3)   42(59.2)   49(69.0)   0(0)   29(40.8) 42(59.2)  
Atypical DHL/THL VS DEL   0.002*   0.056*   0.731*   < 0.001*    0.140
  1. EC extra copies, R rearrangement, DLBCL diffuse large B-cell lymphoma, DHL double hit lymphoma, THL triple hit lymphoma, DEL double expressor lymphoma, GCB germinal center B-cell
  2. *Fisher’s exact test