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Table 1 The relationship between MYC, BCL2 and BCL6 genetic alterations and protein expression

From: Prognostic impact of diffuse large B-cell lymphoma with extra copies of MYC, BCL2 and/or BCL6: comparison with double/triple hit lymphoma and double expressor lymphoma

 

MYC +

P

BCL2 +

P

BCL6 +

P

MYC/BCL2 +

P

GCB

non-GCB

P

MYC normal

42(40.8)

 

76(73.8)

 

73(70.9)

 

36(35.0)

 

39(37.9)

64(62.1)

 

MYC EC

8(57.1)

0.245

11(78.6)

> 0.999*

10(71.4)

> 0.999*

6(42.9)

0.563

6(42.9)

8(57.1)

0.719

MYC R

11(84.6)

0.006*

11(84.6)

0.513*

8(61.5)

0.528

9(69.2)

0.031*

5(38.5)

8(61.5)

0.967

MYC EC VS R

 

0.209*

 

> 0.999*

 

0.695*

 

0.252*

  

0.816

BCL2 normal

36(40.9)

 

59(67.0)

 

62(70.5)

 

26(29.5)

 

34(38.6)

54(61.4)

 

BCL2 EC

16(61.5)

0.064

24(92.3)

0.011*

17(65.4)

0.622

16(61.5)

0.003

7(26.9)

19(73.1)

0.274

BCL2 R

12(63.2)

0.077

18(94.7)

0.021*

15(78.9)

0.579*

12(63.2)

0.005

11(57.9)

8(42.1)

0.123

BCL2 EC VS R

 

0.987

 

> 0.999*

 

0.495*

 

0.987

  

0.027

BCL6 normal

40(43.5)

 

69(75.0)

 

62(67.4)

 

33(35.9)

 

35(38.0)

57(62.0)

 

BCL6 EC

12(63.2)

0.118

16(84.2)

0.555*

13(68.4)

0.930

11(57.9)

0.074

7(36.8)

12(63.2)

0.922

BCL6 R

11(50.0)

0.580

16(72.7)

0.826

19(86.4)

0.115*

9(40.9)

0.660

10(45.5)

12(54.5)

0.523

BCL6 EC VS R

11(64.7)

0.296

14(82.4)

0.451*

11(64.7)

0.255*

10(58.8)

0.187

6(35.3)

11(64.7)

0.676

Conventional DLBCL

23(37.1)

 

42(67.7)

 

44(71.0)

 

18(29.0)

 

26(41.9)

36(58.1)

 

Atypical DHL/THL

8(66.7)

0.107*

10(83.3)

0.491*

9(75.0)

> 0.999*

7(58.3)

0.049

6(50.0)

6(50.0)

0.606

DHL/THL

8(80.0)

0.016*

9(90.0)

0.262*

8(80.0)

0.716*

7(70.0)

0.027*

5(50.0)

5(50.0)

0.633

Atypical DHL/THL VS DHL/THL

 

0.646*

 

> 0.999*

 

> 0.999*

 

0.675*

  

> 0.999*

DEL +

37(100.0)

< 0.001*

37(100.0)

< 0.001*

25(67.6)

0.878

37(100.0)

< 0.001*

10(27.0)

27(73.0)

0.156

DEL -

8(11.3)

 

42(59.2)

 

49(69.0)

 

0(0)

 

29(40.8)

42(59.2)

 

Atypical DHL/THL VS DEL

 

0.002*

 

0.056*

 

0.731*

 

< 0.001*

  

0.140

  1. EC extra copies, R rearrangement, DLBCL diffuse large B-cell lymphoma, DHL double hit lymphoma, THL triple hit lymphoma, DEL double expressor lymphoma, GCB germinal center B-cell
  2. *Fisher’s exact test