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Table 1 The microscopic features with descriptions for each grade (WHO73/ 04)

From: Prognostic value and reproducibility of different microscopic characteristics in the WHO grading systems for pTa and pT1 urinary bladder urothelial carcinomas

  WHO73 WHO04
Grade 1 Grade 2 Grade 3 Low grade High grade
Architecture
 Papillae Delicate Varies Broad, varies Slender Broad
 Superficial layer
(umbrella cell layer)
Usually present Usually present Partially or completely lost Usually present Partially or completely lost
 Papillary fusion Some Varies Common Some Varies
Nuclear arrangement
 Polarity Preserved Moderate loss Lost Preserved, moderate loss Lost
 Maturation Normal Some Lost Preserved, moderate loss Lost
 Cohesion Normal Some Lost Some Lost
Proliferation
 Mitotic figures Rare, basal Lower half Common, atypical Rare Common
Nuclear atypia
 Nuclear enlargement Mild Mild Varies Mild Varies
 Nuclear shape Uniform Moderate variation Pleomorphic Moderate variation Pleomorphic
 Nuclear hyperchromasia Mild Moderate Varies Mild to moderate Varies
 Chromatin pattern Finely granular Granular Coarse Fine Coarse
 Nucleoli Occasional Occasional Common Occasional Common
 Giant nuclei No No Yes No Yes