Feature | n* | AC1/AC2 (95% CI) | Fleiss’ κ (95% CI) | n** | Consensus grade (prob. of progression) | AUCROC (95% CI) *** |
---|---|---|---|---|---|---|
Papillae73 | 36 | 0.62 (0.42 to 0.82) | 0.63 (0.45 to 0.82) | 38 | Delicate (1/10) Varies (4/11) Broad, varies (8/17) | 0.67 (0.51 to 0.83) |
Papilae04 | 36 | 0.61 (0.39 to 0.82) | 0.59 (0.37 to 0.81) | 38 | Slender (3/16) Broad (10/22) | 0.64 (0.49 to 0.80) |
Superficial layer73/04 | 36 | 0.51 (0.30 to 0.73) | 0.50 (0.29 to 0.72) | 37 | Usually present (4/12) Partially lost (8/25) | 0.49 (0.33 to 0.66) |
Papillary fusion73 | 34 | 0.64 (0.44 to 0.84) | 0.67 (0.48 to 0.86) | 36 | Some (2/13) Varies (4/9) Common (7/14) | 0.67 (0.50 to 0.84) |
Papillary fusion04 | 34 | 0.53 (0.32 to 0.75) | 0.53 (0.31 to 0.75) | 36 | Some (4/19) Varies (8/17) | 0.67 (0.51 to 0.84) |
Polarity73 | 38 | 0.68 (0.53 to 0.82) | 0.70 (0.55 to 0.84) | 38 | Preserved (1/9) Moderate (4/14) Lost (8/15) | 0.70 (0.54 to 0.86) |
Polarity04 | 38 | 0.66 (0.47 to 0.86) | 0.63 (0.43 to 0.84) | 38 | Preserved (5/23) Lost (8/15) | 0.67 (0.50 to 0.83) |
Maturation73 | 36 | 0.60 (0.43 to 0.78) | 0.59 (0.42 to 0.76) | 36 | Normal (1/9) Some (5/14) Lost (6/13) | 0.66 (0.49 to 0.83) |
Maturation04 | 36 | 0.62 (0.42 to 0.82) | 0.60 (0.40 to 0.81) | 36 | Some (6/23) Lost (6/13) | 0.60 (0.43 to 0.78) |
Cohesion73 | 37 | 0.57 (0.42 to 0.71) | 0.47 (0.28 to 0.65) | 38 | Normal (1/12) Some (9/21) Lost (3/5) | 0.71 (0.56 to 0.85) |
Cohesion04 | 37 | 0.54 (0.30 to 0.77) | 0.23 (−0.02 to 0.47) | 38 | Some (10/33) Lost (3/5) | 0.58 (0.44 to 0.71) |
Mitosis73 | 38 | 0.47 (0.23 to 0.71) | 0.41 (0.18 to 0.64) | 38 | Rare, basal (8/31) Lower half (1/1) Common, atypical (4/6) | 0.65 (0.50 to 0.80) |
Mitosis04 | 38 | 0.64 (0.43 to 0.85) | 0.49 (0.25 to 0.72) | 38 | Rare (9/32) Common (4/6) | 0.61 (0.47 to 0.76) |
Nuclear enlargement73/04 | 38 | 0.65 (0.45 to 0.85) | 0.65 (0.45 to 0.84) | 38 | Mild (4/19) Varies (9/19) | 0.65 (0.48 to 0.81) |
Nuclear shape73 | 38 | 0.58 (0.41 to 0.74) | 0.51 (0.32 to 0.69) | 38 | Uniform (3/10) Moderate (8/23) Pleomorphic (2/5) | 0.53 (0.36 to 0.71) |
Nuclear shape04 | 38 | 0.58 (0.34 to 0.81) | 0.41 (0.21 to 0.61) | 38 | Moderate (11/33) Pleomorphic (2/5) | 0.52 (0.40 to 0.64) |
Nuclear hyperchromasia73 | 38 | 0.51 (0.38 to 0.65) | 0.51 (0.35 to 0.68) | 38 | Mild (3/11) Moderate (6/17) Varies (4/10) | 0.56 (0.37 to 0.74) |
Nuclear hyperchromasia04 | 38 | 0.51 (0.28 to 0.74) | 0.43 (0.21 to 0.65) | 38 | Mild to moderate (9/28) Varies (4/10) | 0.53 (0.38 to 0.69) |
Chromatin pattern73 | 38 | 0.51 (0.29 to 0.73) | 0.46 (0.26 to 0.67) | 38 | Finely granular (7/25) Granular (4/10) Coarse (2/3) | 0.60 (0.43 to 0.78) |
Chromatin pattern04 | 38 | 0.66 (0.47 to 0.86) | 0.55 (0.31 to 0.79) | 38 | Fine (9/31) Coarse (4/7) | 0.59 (0.45 to 0.74) |
Nucleoli73/04 | 38 | 0.54 (0.33 to 0.76) | 0.54 (0.33 to 0.75) | 38 | Occasional (2/16) Common (11/22) | 0.70 (0.56 to 0.85) |
Giant nuclei | 38 | 0.85 (0.72 to 0.98) | 0.78 (0.59 to 0.98) | 38 | No (8/28) Yes (5/10) | 0.59 (0.43 to 0.75) |