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Table 2 Reproducibility and prognostic value for each of the microscopic characteristics

From: Prognostic value and reproducibility of different microscopic characteristics in the WHO grading systems for pTa and pT1 urinary bladder urothelial carcinomas

Feature n* AC1/AC2 (95% CI) Fleiss’ κ (95% CI) n** Consensus grade
(prob. of progression)
AUCROC (95% CI) ***
Papillae73 36 0.62 (0.42 to 0.82) 0.63 (0.45 to 0.82) 38 Delicate (1/10)
Varies (4/11)
Broad, varies (8/17)
0.67 (0.51 to 0.83)
Papilae04 36 0.61 (0.39 to 0.82) 0.59 (0.37 to 0.81) 38 Slender (3/16)
Broad (10/22)
0.64 (0.49 to 0.80)
Superficial layer73/04 36 0.51 (0.30 to 0.73) 0.50 (0.29 to 0.72) 37 Usually present (4/12)
Partially lost (8/25)
0.49 (0.33 to 0.66)
Papillary fusion73 34 0.64 (0.44 to 0.84) 0.67 (0.48 to 0.86) 36 Some (2/13)
Varies (4/9)
Common (7/14)
0.67 (0.50 to 0.84)
Papillary fusion04 34 0.53 (0.32 to 0.75) 0.53 (0.31 to 0.75) 36 Some (4/19)
Varies (8/17)
0.67 (0.51 to 0.84)
Polarity73 38 0.68 (0.53 to 0.82) 0.70 (0.55 to 0.84) 38 Preserved (1/9)
Moderate (4/14)
Lost (8/15)
0.70 (0.54 to 0.86)
Polarity04 38 0.66 (0.47 to 0.86) 0.63 (0.43 to 0.84) 38 Preserved (5/23)
Lost (8/15)
0.67 (0.50 to 0.83)
Maturation73 36 0.60 (0.43 to 0.78) 0.59 (0.42 to 0.76) 36 Normal (1/9)
Some (5/14)
Lost (6/13)
0.66 (0.49 to 0.83)
Maturation04 36 0.62 (0.42 to 0.82) 0.60 (0.40 to 0.81) 36 Some (6/23)
Lost (6/13)
0.60 (0.43 to 0.78)
Cohesion73 37 0.57 (0.42 to 0.71) 0.47 (0.28 to 0.65) 38 Normal (1/12)
Some (9/21)
Lost (3/5)
0.71 (0.56 to 0.85)
Cohesion04 37 0.54 (0.30 to 0.77) 0.23 (−0.02 to 0.47) 38 Some (10/33)
Lost (3/5)
0.58 (0.44 to 0.71)
Mitosis73 38 0.47 (0.23 to 0.71) 0.41 (0.18 to 0.64) 38 Rare, basal (8/31)
Lower half (1/1)
Common, atypical (4/6)
0.65 (0.50 to 0.80)
Mitosis04 38 0.64 (0.43 to 0.85) 0.49 (0.25 to 0.72) 38 Rare (9/32)
Common (4/6)
0.61 (0.47 to 0.76)
Nuclear enlargement73/04 38 0.65 (0.45 to 0.85) 0.65 (0.45 to 0.84) 38 Mild (4/19)
Varies (9/19)
0.65 (0.48 to 0.81)
Nuclear shape73 38 0.58 (0.41 to 0.74) 0.51 (0.32 to 0.69) 38 Uniform (3/10)
Moderate (8/23)
Pleomorphic (2/5)
0.53 (0.36 to 0.71)
Nuclear shape04 38 0.58 (0.34 to 0.81) 0.41 (0.21 to 0.61) 38 Moderate (11/33)
Pleomorphic (2/5)
0.52 (0.40 to 0.64)
Nuclear hyperchromasia73 38 0.51 (0.38 to 0.65) 0.51 (0.35 to 0.68) 38 Mild (3/11)
Moderate (6/17)
Varies (4/10)
0.56 (0.37 to 0.74)
Nuclear hyperchromasia04 38 0.51 (0.28 to 0.74) 0.43 (0.21 to 0.65) 38 Mild to moderate (9/28)
Varies (4/10)
0.53 (0.38 to 0.69)
Chromatin pattern73 38 0.51 (0.29 to 0.73) 0.46 (0.26 to 0.67) 38 Finely granular (7/25)
Granular (4/10)
Coarse (2/3)
0.60 (0.43 to 0.78)
Chromatin pattern04 38 0.66 (0.47 to 0.86) 0.55 (0.31 to 0.79) 38 Fine (9/31)
Coarse (4/7)
0.59 (0.45 to 0.74)
Nucleoli73/04 38 0.54 (0.33 to 0.76) 0.54 (0.33 to 0.75) 38 Occasional (2/16)
Common (11/22)
0.70 (0.56 to 0.85)
Giant nuclei 38 0.85 (0.72 to 0.98) 0.78 (0.59 to 0.98) 38 No (8/28)
Yes (5/10)
0.59 (0.43 to 0.75)
  1. AC1/ AC2 Gwet’s AC1/ AC2 coefficient, CI Confidence interval, AUCROC Area under Receiver Operating Characteristics Curve.
  2. * Number of cases evaluated by all three pathologists
  3. ** Number of cases for which consensus was reached