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Table 2 Reproducibility and prognostic value for each of the microscopic characteristics

From: Prognostic value and reproducibility of different microscopic characteristics in the WHO grading systems for pTa and pT1 urinary bladder urothelial carcinomas

Feature

n*

AC1/AC2 (95% CI)

Fleiss’ κ (95% CI)

n**

Consensus grade

(prob. of progression)

AUCROC (95% CI) ***

Papillae73

36

0.62 (0.42 to 0.82)

0.63 (0.45 to 0.82)

38

Delicate (1/10)

Varies (4/11)

Broad, varies (8/17)

0.67 (0.51 to 0.83)

Papilae04

36

0.61 (0.39 to 0.82)

0.59 (0.37 to 0.81)

38

Slender (3/16)

Broad (10/22)

0.64 (0.49 to 0.80)

Superficial layer73/04

36

0.51 (0.30 to 0.73)

0.50 (0.29 to 0.72)

37

Usually present (4/12)

Partially lost (8/25)

0.49 (0.33 to 0.66)

Papillary fusion73

34

0.64 (0.44 to 0.84)

0.67 (0.48 to 0.86)

36

Some (2/13)

Varies (4/9)

Common (7/14)

0.67 (0.50 to 0.84)

Papillary fusion04

34

0.53 (0.32 to 0.75)

0.53 (0.31 to 0.75)

36

Some (4/19)

Varies (8/17)

0.67 (0.51 to 0.84)

Polarity73

38

0.68 (0.53 to 0.82)

0.70 (0.55 to 0.84)

38

Preserved (1/9)

Moderate (4/14)

Lost (8/15)

0.70 (0.54 to 0.86)

Polarity04

38

0.66 (0.47 to 0.86)

0.63 (0.43 to 0.84)

38

Preserved (5/23)

Lost (8/15)

0.67 (0.50 to 0.83)

Maturation73

36

0.60 (0.43 to 0.78)

0.59 (0.42 to 0.76)

36

Normal (1/9)

Some (5/14)

Lost (6/13)

0.66 (0.49 to 0.83)

Maturation04

36

0.62 (0.42 to 0.82)

0.60 (0.40 to 0.81)

36

Some (6/23)

Lost (6/13)

0.60 (0.43 to 0.78)

Cohesion73

37

0.57 (0.42 to 0.71)

0.47 (0.28 to 0.65)

38

Normal (1/12)

Some (9/21)

Lost (3/5)

0.71 (0.56 to 0.85)

Cohesion04

37

0.54 (0.30 to 0.77)

0.23 (−0.02 to 0.47)

38

Some (10/33)

Lost (3/5)

0.58 (0.44 to 0.71)

Mitosis73

38

0.47 (0.23 to 0.71)

0.41 (0.18 to 0.64)

38

Rare, basal (8/31)

Lower half (1/1)

Common, atypical (4/6)

0.65 (0.50 to 0.80)

Mitosis04

38

0.64 (0.43 to 0.85)

0.49 (0.25 to 0.72)

38

Rare (9/32)

Common (4/6)

0.61 (0.47 to 0.76)

Nuclear enlargement73/04

38

0.65 (0.45 to 0.85)

0.65 (0.45 to 0.84)

38

Mild (4/19)

Varies (9/19)

0.65 (0.48 to 0.81)

Nuclear shape73

38

0.58 (0.41 to 0.74)

0.51 (0.32 to 0.69)

38

Uniform (3/10)

Moderate (8/23)

Pleomorphic (2/5)

0.53 (0.36 to 0.71)

Nuclear shape04

38

0.58 (0.34 to 0.81)

0.41 (0.21 to 0.61)

38

Moderate (11/33)

Pleomorphic (2/5)

0.52 (0.40 to 0.64)

Nuclear hyperchromasia73

38

0.51 (0.38 to 0.65)

0.51 (0.35 to 0.68)

38

Mild (3/11)

Moderate (6/17)

Varies (4/10)

0.56 (0.37 to 0.74)

Nuclear hyperchromasia04

38

0.51 (0.28 to 0.74)

0.43 (0.21 to 0.65)

38

Mild to moderate (9/28)

Varies (4/10)

0.53 (0.38 to 0.69)

Chromatin pattern73

38

0.51 (0.29 to 0.73)

0.46 (0.26 to 0.67)

38

Finely granular (7/25)

Granular (4/10)

Coarse (2/3)

0.60 (0.43 to 0.78)

Chromatin pattern04

38

0.66 (0.47 to 0.86)

0.55 (0.31 to 0.79)

38

Fine (9/31)

Coarse (4/7)

0.59 (0.45 to 0.74)

Nucleoli73/04

38

0.54 (0.33 to 0.76)

0.54 (0.33 to 0.75)

38

Occasional (2/16)

Common (11/22)

0.70 (0.56 to 0.85)

Giant nuclei

38

0.85 (0.72 to 0.98)

0.78 (0.59 to 0.98)

38

No (8/28)

Yes (5/10)

0.59 (0.43 to 0.75)

  1. AC1/ AC2 Gwet’s AC1/ AC2 coefficient, CI Confidence interval, AUCROC Area under Receiver Operating Characteristics Curve.
  2. * Number of cases evaluated by all three pathologists
  3. ** Number of cases for which consensus was reached