Table 2 Gene mutations detected in the lung, kidney and colon tumor samples
Lung | Kidney | Colon | White blood cell | |
|---|---|---|---|---|
Tumor Mutation Burden (mutations/Mb) | 15.1 | 14.3 | 7.9 | – |
Gene mutations detected | Allele frequency | |||
FANCC c.339G > A (p.W113X) | 36.45% | 39.67% | 46.57% | detected |
KMT2C c.962G > A (p.S321 N) | 11.81% | 14.62% | 17.45% | – |
TP53 c.614A > G (p.Y205C) | 31.74% | 24.91% | – | – |
CDKN2A c.151-1G > T | 24.40% | 15.54% | – | – |
LRP1B c.55A > G (p.R19G) | 49.76% | 46.88% | – | – |
LRP1B c.4258G > C (p.D1420H) | 17.64% | 15.00% | – | – |
SMARCA4 c.2946G > T (p.K982 N) | 30.56% | 26.12% | – | – |
SMARCA4 c.3529G > T (p.D1177Y) | 26.92% | 27.18% | – | – |
SLX4 c.4976C > T (p.P1659L) | 22.82% | 6.83% | – | – |
PTPRD c.2350-9 T > A | 22.21% | 18.26% | – | – |
PTPRD c.4944 T > A (p.F1648 L) | 9.66% | – | – | – |
MED12 c.3089C > T (p.A1030V) | 13.64% | – | – | – |
PREX2 c.1188C > G (p.I396M) | 12.02% | – | – | – |
FAT3 c.8425G > T (p.D2809Y) | 7.25% | – | – | – |
ERBB2 amplification | CN = 3.38 | – | – | – |
STAT3 amplification | CN = 3.66 | – | – | – |
RAC1 amplification | – | CN = 3.07 | – | – |
ATM c.1562G > C (p.R521T) | – | 8.04% | – | – |
SDHA c.940G > A (p.E314K) | – | 13.71% | – | – |
ATR c.7del (p.Q3fs) | – | 8.88% | – | – |
RANBP2 c.5632 T > G (p.S1878A) | – | 4.47% | – | – |
TP53 c.818G > A (p.R273H) | – | – | 16.77% | – |
PTPRT c.230 T > C (p.V77A) | – | – | 29.21% | – |
TCF7L2 c.1408G > T (p.V470F) | – | – | 15.71% | – |
APC c.4216C > T (p.Q1406X) | – | – | 14.99% | – |
DICER1 c.2077G > A (p.V693I) | – | – | 14.86% | – |