Table 1 Analysis of the association between expression of Mcl-1 and Ki-67 PI and c-PARP AI and clinicopathological features of NSCLC (n = 350)
Clinicopathological features (n) | Mcl-1 | PI | AI | Mcl-1/PI # | Mcl-1/AI# | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High (%) | Low (%) | P-value | High (%) | Low (%) | P-value | High (%) | Low (%) | P-value | P+ (%) | N− (%) | P-value | P+ (%) | N− (%) | P-value | |
Age (years) | |||||||||||||||
  ≤ 50 (n = 95) | 62 (65.3) | 33 (34.7) |  | 52 (54.7) | 43 (45.3) |  | 37 (38.9) | 58 (61.1) |  | 34 (35.8) | 61 (64.2) |  | 42 (44.2) | 53 (55.8) |  |
 >50 (n = 255) | 164 (64.3) | 91 (35.7) | .901 | 160 (62.7) | 95 (37.3) | 0.178 | 112 (43.9) | 143 (56.1) | 0.466 | 115 (45.1) | 140 (54.9) | 0.114 | 103 (40.4) | 152 (59.6) | 0.543 |
Gender | |||||||||||||||
 Male (n = 266) | 171 (64.3) | 95 (35.7) |  | 172 (64.7) | 94 (35.3) |  | 127 (47.7) | 139 (52.3) |  | 121 (45.5) | 145 (54.5) |  | 102 (38.3) | 164 (61.7) |  |
 Female (n = 84) | 55 (65.5) | 29 (34.5) | 0.896 | 40 (47.6) | 44 (52.4) | 0.007* | 22 (26.2) | 62 (73.8) | 0.001* | 28 (33.3) | 56 (66.7) | 0.058 | 43 (51.2) | 41 (48.8) | 0.042* |
Clinical stages | |||||||||||||||
 Stage I-II (n = 151) | 91 (60.3) | 60 (39.7) |  | 95 (62.1) | 56 (37.1) |  | 69 (45.7) | 82 (54.3) |  | 61 (40.4) | 90 (59.6) |  | 56 (37.1) | 95 (62.9) |  |
 Stage III (n = 199) | 135 (67.8) | 64 (32.2) | 0.145 | 117 (58.8) | 82 (41.2) | 0.442 | 80 (40.2) | 119 (59.8) | 0.327 | 88 (44.2) | 111 (55.8) | 0.513 | 89 (44.7) | 110 (55.3) | 0.156 |
LN status | |||||||||||||||
 LNM (n = 210) | 137 (65.2) | 73 (34.8) |  | 127 (60.5) | 83 (39.5) |  | 86 (41.0) | 124 (59.0) |  | 90 (42.9) | 120 (57.1) |  | 97 (43.3) | 119 (56.7) |  |
 No LNM (n = 140) | 89 (63.6) | 51 (36.4) | 0.820 | 85 (60.7) | 55 (39.3) | 1.000 | 63 (45.0) | 77 (55.0) | 0.508 | 59 (42.1) | 81 (57.9) | 0.913 | 54 (38.6) | 86 (61.4) | 0.438 |
Histological type | |||||||||||||||
 SCC (N = 154) | 85 (55.2) | 69 (44.8) |  | 113 (73.4) | 41 (26.6) |  | 95 (66.7) | 59 (83.3) |  | 71 (46.1) | 83 (53.9) |  | 37 (24.0) | 117 (76.0) |  |
 ADC (N = 196) | 142 (71.9) | 55 (28.1) | 0.002* | 99 (50.5) | 97 (49.5) | 0.000* | 54 (27.6) | 142 (72.4) | 0.000* | 78 (39.8) | 118 (60.2) | 0.276 | 108 (55.1) | 88 (44.9) | 0.000* |
Pathological grade | |||||||||||||||
 Well (n = 6) | 6 (100.0) | 0 (0.0) |  | 2 (33.3) | 4 (66.7) |  | 1 (16.7) | 5 (83.3) |  | 2 (33.3) | 4 (66.7) |  | 5 (83.3) | 1 (16.7) |  |
 Moderate (n = 146) | 94 (66.4) | 52 (35.6) |  | 88 (60.3) | 58 (39.7) |  | 61 (41.8) | 85 (58.2) |  | 58 (39.7) | 88 (60.3) |  | 65 (44.5) | 81 (55.5) |  |
 Poor (n = 198) | 126 (63.6) | 72 (36.4) | 0.185 | 122 (61.6) | 76 (38.4) | 0.375 | 87 (43.9) | 111 (56.1) | 0.399 | 89 (44.9) | 109 (55.1) | 0.562 | 75 (37.9) | 123 (62.1) | 0.051 |
Survival status | |||||||||||||||
 Alive (n = 187) | 105 (56.1) | 82 (43.9) |  | 113 (60.4) | 74 (39.6) |  | 97 (51.9) | 90 (48.1) |  | 65 (34.8) | 122 (65.2) |  | 60 (32.1) | 127 (67.9) |  |
 Dead (n = 163) | 121 (74.2) | 42 (25.8) | 0.000* | 99 (60.7) | 64 (39.3) | 1.000 | 52 (31.9) | 111 (68.1) | 0.000* | 84 (51.5) | 79 (48.5) | 0.002* | 85 (52.1) | 78 (47.9) | 0.000* |