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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma

Fig. 4

Loss of CPXM2 decreased the on the proliferation and migration ability of osteosarcoma U2OS cells. a Western blotting was used to examine the effects of silencing CPXM2 and EMT process in the osteosarcoma U2OS cells. b Growth curve of osteosarcoma cells detected by the CCK-8 assay. c The abilities of osteosarcoma cells to form colonies under 2D culture condition were determined through colony formation assay. d The Transwell chambers method was utilized to explore the impact of CPXM2 silence on the invasive ability of osteosarcoma U2OS cells in vitro. e The wound-healing assay was utilized to explore the migration ability of osteosarcoma cells in vitro. **P < 0.01, compared with the scramble group. CPXM2, Carboxypeptidase X, M14 family member 2; EMT, epithelial mesenchymal transition; OD, optical density

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