Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma

Table 1 Expression of CPXM2 and clinicopathological characteristics in osteosarcoma patients

Item	N	CPXM2 positive	CPXM2 negative	P
Tumor tissue	36	21	15	< 0.001^*
Noncancerous bone tissue	36	10	26
Age (years)
≤ 19	17	10	7	0.912^a
> 19	19	11	8
Sex
Male	21	12	9	0.876^a
Female	15	9	6
Histologic grade
I	4	1	3
II	7	4	3	< 0.05^*
III	25	16	9
Histologic subtypes
Osteoblastic	18	15	3	< 0.01^*
Fibroblastic	4	1	3
Chondroblastic	3	1	2
Mixed	11	4	7
Enneking clinical stages
I-II	14	5	9	< 0.01^*
III	22	16	6
Response to chemotherapy
Poor	9	5	4	0.926^a
Good	7	4	3
NA (n = 12)	20
TNM stages
I- II	14	5	9	< 0.01^*
III-IV	22	16	6
Pulmonary metastasis
+	22	17	5	< 0.001^*
-	14	4	10
History of trauma or bone fracture
+	11	7	4	0.756
-	25	14	11
E-Cadherin
+	12	4	8	< 0.01^*
-	24	17	7

^aStatistical significance was determined with the χ² test/χ² Goodness-of-Fit Test
^*Statistical significance was found with the Chi-square test/Chi-Square Goodness-of-Fit Test

ISSN: 1746-1596