Diagnostic Pathology

Table 2 Cox regression analysis in the patients with OS

From: MicroRNA-99b predicts clinical outcome of osteosarcoma and suppresses tumor cell proliferation, migration and invasion

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P value	HR	95% CI	P value
miR-99b	3.012	1.622–6.185	0.009	2.897	1.231–4.628	0.019
Low vs. High	3.012	1.622–6.185	0.009	2.897	1.231–4.628	0.019
Age (years)	0.867	0.456–1.649	0.664	0.937	0.482–1.822	0.848
> 20 vs. ≤ 20	0.867	0.456–1.649	0.664	0.937	0.482–1.822	0.848
Gender	1.258	0.650–2.435	0.496	1.117	0.552–2.258	0.758
Male vs. Female	1.258	0.650–2.435	0.496	1.117	0.552–2.258	0.758
Tumor size (cm)	0.940	0.490–1.803	0.853	1.022	0.517–2.020	0.950
> 8 vs. ≤ 8	0.940	0.490–1.803	0.853	1.022	0.517–2.020	0.950
Distant metastasis	2.018	1.211–3.185	0.033	1.279	0.631–2.595	0.495
Positive vs. Negative	2.018	1.211–3.185	0.033	1.279	0.631–2.595	0.495
Differentiation	1.912	1.035–2.585	0.043	1.322	0.668–2.614	0.423
Poor vs. Well/moderate	1.912	1.035–2.585	0.043	1.322	0.668–2.614	0.423
Clinical stage	1.969	1.104–2.613	0.038	1.758	0.755–4.093	0.191
IIB - III vs. IA - IIA	1.969	1.104–2.613	0.038	1.758	0.755–4.093	0.191

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ISSN: 1746-1596

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