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Table 2 Tumor microenvironment analysis: Comparing average FOXP3 Treg and CD8 TIL density at the center or edge of tumor lesions

From: Clinicopathologic and microenvironmental analysis of primary cutaneous CD30-positive lymphoproliferative disorders: a 26 year experience from an academic medical center in Brazil

Tumor Microenvironment

Diagnosis (n)

Mean (Standard deviation)

*LyP vs pcALCL

Tumor center CD8 TIL density (per hpf)

LyP (8)

87 (69)

p = 0.14

pcALCL (8)

47 (39)

Tumor center FOXP3 Tregs density (per hpf)

LyP (8)

56 (41)

p = 0.05

pcALCL (9)

23 (27)

Tumor edge CD8 TIL density (per hpf)

LyP (8)

67 (18)

p = 0.05

pcALCL (6)

130 (79)

Tumor edge FOXP3 Treg density (per hpf)

LyP (8)

31 (23)

p = 0.61

pc-ALCL (6)

36 (21)

Ratio CD8 TIL edge/center

LyP (8)

1.0 (0.5)

p = 0.04

pcALCL (6)

2.6 (1.9)

Ratio FOXP3 Treg edge/center

LyP (8)

0.9 (0.9)

p = 0.05

pcALCL (6)

3.6 (3.6)

  1. *Kruskal-Wallis test; LyP Lymphomatoid papulomatosis, pcALCL primary cutaneous anaplastic large cell lymphoma, TILs tumor infiltrating lymphocytes, HPF High-power fields