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Table 2 Tumor microenvironment analysis: Comparing average FOXP3 Treg and CD8 TIL density at the center or edge of tumor lesions

From: Clinicopathologic and microenvironmental analysis of primary cutaneous CD30-positive lymphoproliferative disorders: a 26 year experience from an academic medical center in Brazil

Tumor Microenvironment Diagnosis (n) Mean (Standard deviation) *LyP vs pcALCL
Tumor center CD8 TIL density (per hpf) LyP (8) 87 (69) p = 0.14
pcALCL (8) 47 (39)
Tumor center FOXP3 Tregs density (per hpf) LyP (8) 56 (41) p = 0.05
pcALCL (9) 23 (27)
Tumor edge CD8 TIL density (per hpf) LyP (8) 67 (18) p = 0.05
pcALCL (6) 130 (79)
Tumor edge FOXP3 Treg density (per hpf) LyP (8) 31 (23) p = 0.61
pc-ALCL (6) 36 (21)
Ratio CD8 TIL edge/center LyP (8) 1.0 (0.5) p = 0.04
pcALCL (6) 2.6 (1.9)
Ratio FOXP3 Treg edge/center LyP (8) 0.9 (0.9) p = 0.05
pcALCL (6) 3.6 (3.6)
  1. *Kruskal-Wallis test; LyP Lymphomatoid papulomatosis, pcALCL primary cutaneous anaplastic large cell lymphoma, TILs tumor infiltrating lymphocytes, HPF High-power fields