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Table 7 Association of PRMT1, ZEB1, RUNX1, and TWIST1 with WNT-β-catenin/EMT hallmarks (β-catenin, N- and E-cadherin) in ccRCC

From: PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

Transcription factor Wnt-β-catenin/EMT hallmarks
Aberrant β -catenin P value N-cadherin+ P value E-cadherin- P value
PRMT1
+ 37/37 (100) 1 58/69 (84.1) 0.878 20/66 (30.3) 0.468
- 36/36 (100) 40/47 (85.1) 11/46 (24.0)
ZEB1
+ 21/21 (100) 1 33/37 (89.2) 0.380 12/36 (33.3) 0.280
- 52/52 (100) 63/76 (83.0) 17/73 (23.6)
RUNX1
+ 46/46 (100) 1 65/70 (92.8) 0.003* 14/70 (20.0) 0.019*
- 26/26 (100) 32/45 (71.1) 17/42 (40.5)
TWIST1
n+/−c 20/20 (100) 1 38/46 (82.6) 0.563 14/46 (30.4) 0.528
c 52/52 (100) 58/67 (86.6) 16/64 (25.0)
- 1/1 (100) 2/3 (66.5) 1/2 (50.0)
  1. Abbreviations: PRMT1 protein arginine methyltransferase 1; ZEB1, Zinc Finger E-Box Binding Homeobox 1; RUNX1, Runt-related transcription factor 1; TWIST1, Twist Family BHLH Transcription Factor 1; n, nuclear; c, cytoplasmic; +, positive; −, negative. *Statistically significant p-value
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