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Table 7 Association of PRMT1, ZEB1, RUNX1, and TWIST1 with WNT-β-catenin/EMT hallmarks (β-catenin, N- and E-cadherin) in ccRCC

From: PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

Transcription factor

Wnt-β-catenin/EMT hallmarks

Aberrant β -catenin

P value

N-cadherin+

P value

E-cadherin-

P value

PRMT1

 +

37/37 (100)

1

58/69 (84.1)

0.878

20/66 (30.3)

0.468

 -

36/36 (100)

40/47 (85.1)

11/46 (24.0)

ZEB1

 +

21/21 (100)

1

33/37 (89.2)

0.380

12/36 (33.3)

0.280

 -

52/52 (100)

63/76 (83.0)

17/73 (23.6)

RUNX1

 +

46/46 (100)

1

65/70 (92.8)

0.003*

14/70 (20.0)

0.019*

 -

26/26 (100)

32/45 (71.1)

17/42 (40.5)

TWIST1

 n+/−c

20/20 (100)

1

38/46 (82.6)

0.563

14/46 (30.4)

0.528

 c

52/52 (100)

58/67 (86.6)

16/64 (25.0)

 -

1/1 (100)

2/3 (66.5)

1/2 (50.0)

  1. Abbreviations: PRMT1 protein arginine methyltransferase 1; ZEB1, Zinc Finger E-Box Binding Homeobox 1; RUNX1, Runt-related transcription factor 1; TWIST1, Twist Family BHLH Transcription Factor 1; n, nuclear; c, cytoplasmic; +, positive; −, negative. *Statistically significant p-value
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Diagnostic Pathology

ISSN: 1746-1596

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