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Table 8 Survival analysis. Mean survival of the patients within all types (n = 194) and ccRCC (n = 120); univariate and multivariate cancer-specific survival in the patients with ccRCC according to analyzed immunohistochemical markers and clinic-pathologic parameters

From: PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

Prognostic factors Cancer-specific survival (months)
     Univariate Multivariate
All types mean (95% CI) p-value ccRCC mean (95% CI) p-value Hazard ratio (95% CI) p-value Hazard ratio (95%CI) p-value
PRMT1
 positive 78 (73–84) 0.009* 74 (66–82) 0.029* 0.504 (0.269–0.947)
Ref.
0.033* 0.622 (0.326–1.188) 0.150
 negative 56 (48–63) 51 (42–61)
ZEB1
 positive 83 (76–91) 0.011* 80 (70–90) 0.009* 0.344 (0.140–0.801) 0.014* 0.367 (0.152–0.889) 0.026
 negative 68 (61–74) 52 (45–60)
RUNX1
 positive 75 (68–82) 0.937 67 (60–74) 0.506 0.872 (0.463–1.644) 0.673 N/A  
 negative 69 (61–78) 57 (48–66)
TWIST1
 positive 73 (68–78) 0.886 67 (60–74) 0.878 1.168 (0.159–8.553) 0.879 N/A  
 negative 54 (34–75) 54 (34–75)
Grade N/A       
 Low 67 (62–72) <0.001* 5.802 (3.000–11.222) <0.001* 6.284 (3.175–12.438) <0.001*
 High 25 (18–32)
Stage N/A       
 Low 70 (63–76) <0.001* 1.062 (0.849–1.330) 0.597 1.187 (0.912–1.547) 0.203
 High 48 (36–60)
 PN 63 (51–74)
Gender
 Male 75 (66–83) 0.686 58 (51–65) 0.736 1.123 (0.569–2.218) 0.737 N/A  
 Female 72 (66–78) 70 (58–81)
  1. Abbreviations: PRMT1 protein arginine methyltransferase 1, ZEB1 Zinc Finger E-Box Binding Homeobox 1, RUNX1 Runt-related transcription factor 1, TWIST1 Twist Family BHLH Transcription Factor 1, CI confidence interval, PN partial nephrectomy, ref. referent value. *Statistically significant p-value