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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Aberrant expression of miR-214 is associated with obesity-induced insulin resistance as a biomarker and therapeutic

Fig. 4

Establishment of obesity-associated IR animal and cell models. a. Body weight (BW) in IR animals was increased compared with the normal controls. b. Glucose tolerance was significantly impaired in the IR group compared with the NC group. c. Insulin tolerance in IR group was lower than that in the NC group. d. AUCs of IR group for OGTT and IPITT were all increased compared with that in NC group. e. IR animal had higher HOMA-IR than that in the normal rats. f. Insulin-stimulated glucose uptake was suppressed by PA treatment in the 3 T3-L1 cells compared with the normal adipocyte. *P < 0.05 and **P < 0.01

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