Fig. 6

Effects of miR-214 on the IR conditions in the established IR models. a-c. VG treatment or the overexpression of miR-214 in IR rats rescued the glucose and insulin tolerance, and the combination of these two methods resulted more improved glucose and insulin tolerance. d. HOMA-IR of the IR animals was decreased by VG treatment or the upregulation of miR-214. e. Blocked insulin-stimulated glucose uptake by PA treatment was rescued by the treatment with VG or the overexpression of miR-214, and the combined therapy of VG treatment and miR-214 overexpression could further improve the glucose uptake ability. *P < 0.05 and **P < 0.01 compared to the IR group; ^#P < 0.05 compared to the VG group; ^&P < 0.05 compared to the miR-214 mimic group; ^▲P < 0.05, ^▲▲P < 0.01 compared to the insulin negative group