Fig. 1
a Representative figure showing the hematoxylin and eosin staining of the prostate needle-biopsy specimens. The enlarged picture shows the tumor with Gleason patterns 4 and 5. Scale bar, 100 μm. b Magnetic resonance imaging (MRI) showing a prostatic tumor invading the seminal vesicles (arrow). c Skeletal scintigraphy at diagnosis. d Skeletal scintigraphy after the sixth cycle of docetaxel. e Skeletal scintigraphy 5 months after enzalutamide was started. Bone metastases were exacerbated (arrow)