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Table 1 Clinicopathological characteristics of 21 thyroid Burkitt’s lymphomas by meta-analysis of the literature

From: Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis

Age (years)6–75 (median 39.3)
Sex (Male/Female)13/8
Clinical presentation
 Thyroid mass17/18 (94.4%)
 Rapid growing12/18 (66.7%)
 Dyspnea11/18 (61.1%)
 Dysphagia3/18 (16.7%)
 Thyrotoxicosis1/18 (5.6%)
 Cavernous sinus syndrome1/18 (5.6%)
 *B symptoms4/14 (28.6%)
 Associated immuosuppressive condition0/21 (0%)
Tumor size (mm) (median size)20–105 (59)
Other organ involvement at diagnosis11/21 (52.4%)
Lymph nodes involvement11/21 (52.4%)
 Above diaphragm7/11 (63.6%)
 Above and below diaphragm4/11 (36.4%)
Clinical stage at presentation
 I6/21 (28.6%)
 II2/21 (9.5%)
 III2/21 (9.5%)
 IV11/21 (52.4%)
Elevated thyroid function2/8 (25%)
Elevated TSH1/2 (50%)
Elevated thyroglobulin1/2 (50%)
Elevated thyroid antibody4/8 (50%)
Hashimoto’s thyroiditis5/7 (71.4%)
Immunohistochemistry
 CD30/7(0%)
 CD50/8(0%)
 CD1014/14 (100%);
 CD20 (n = 18)18/18 (100%)
 CD21 (n = 2)0 (0%)
 CD30 (n = 2)0 (0%)
 CD43 (n = 3)1/3 (33.3%)
 CD79a (n = 5)5/5 (100%)
 TDT (n = 3)0 (0%)
 IgG (n = 1)0 (0%)
 IgA (n = 1)0 (0%)
 IgM (n = 1)1/1 (100%)
 Kappa (n = 2)1/2 (50%)
 Lambda (n = 1)1/1 (100%)
 Bcl-2 (n = 10)0 (0%)
 Bcl −6 (n = 6)5/6 (83.3%)
 MUM-1 (n = 2)1/2 (50%)
 p16 (n = 1)1/1 (100%)
 p53 (n = 1)0/1 (0%)
 Ki-67 labelling index (> 90%)19/19 (100%)
 MDM2 (n = 1)1/1 (100%)
EBER ISH0/12 (0%)
Translocation t(8;14) (n = 12)12/12 (100%)
CD10 + (Flow cytometry)5/5 (100%)
Treatment
 Chemotherapy only12/20 (60%)
 Surgery + Chemotherapy7/20 (35%)
 Surgery + Chemotherapy + Radiotherapy1/20 (5%)
Follow-up (months) (median)0.5–361(46.5 m)
Clinical outcome
 Alive with complete remission14/19 (73.7%)
 Alive with persistent disease1/19 (5.3%)
 Dead of disease4/19 (21.1%)
  1. EBER ISH Epstein - Barr virus Small RNAs In Situ Hybridization, FISH fluorescence in situ hybridization, LINAC Linear particle accelerator therapy
  2. *B symptoms: systemic symptoms of fever, night sweats, or weight loss