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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Squamous cell carcinoma with sarcomatoid differentiation or carcinosarcoma of the uterine cervix associated with HPV33 infection: report of a rare case

Fig. 3

Scans of histological slides stained immunohistochemically. AE1/3 (11,2x): note the strong diffuse positivity in the epithelioid part of tumor (left) and weaker, but unequivocal diffuse positivity in the sarcomatoid part, in the upper right corner in detail (5,9x). EMA (7,8x): Note the heterogenous positivity in both epithelioid (left) and sarcomatoid (right) parts of the tumor. Vimentin (29,2x): note the strong positivity in the cervical stroma (left) and in the sarcomatoid part (right) and negativity in the accompanying HSIL (in the middle). P63 (11,2x): note the diffuse nuclear positivity in the epithelioid part (left) and negativity in the sarcomatoid tumor (right). HMWK (26,5x): note the positivity in the epithelioid tumor bud (in the middle) and full negativity in the sarcomatoid part. P16 (7,1x) note the strong and diffuse positivity in both parts of the tumor. Ki67 (16,6x): note the brisk proliferation activity in approximately 80% of tumor cells in both parts

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