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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

Fig. 1

Case of melanoma in situ positive by fluorescence in-situ hybridization (FISH) detection. a Melanocytes proliferated successively or in nests in the basal layer of the epidermis (hematoxylin and eosin, H&E staining), (b) high-power magnification showed moderate to severe atypia of the melanocytes(H&E staining), (c-f) FISH images showed the (c) gain of CCND1 (green signals), (d) gain of RREB1 (red signals), and (f) loss of MYB (gold signals) relative to CEP6 (aqua signals). While the gain of RREB1(d) relative to CEP6 (e) was not observed

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Diagnostic Pathology

ISSN: 1746-1596

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